2024-01-17 01:00:57
hy ‘It’s On Salad’. (Photo = provided by hy)
‘Calorie restriction’ diets that reduce food intake are known to slow aging and increase lifespan. An American research team discovered that a specific diet gene called ‘OXR1’ plays a role here.
The Buck Institute in the U.S. published research results on fruit flies and human cells showing that OXR1 plays a role in calorie-restricted diets extending lifespan and slowing brain aging. The results of this study were published in the international academic journal ‘Nature Communications’ on the 11th.
The team conducted in-depth tests to determine how this gene, which is active in neurons, affects overall lifespan. The results showed that OXR1 affects ‘retromers’, protein complexes essential for the recycling of cellular proteins and lipids. discovered that Retromer dysfunction is known to be associated with age-related neurodegenerative diseases, especially Alzheimer’s disease and Parkinson’s disease.
The research team also analyzed that dietary habits that reduce food intake improved the expression of OXR1. The research team said, “Diet affects this gene,” and “Eating less food strengthens the mechanism by which proteins are properly sorted in cells and enhances the expression of OXR1.”
The research team also discovered that increasing a specific diet gene (OXR1 gene) known as ‘mtd’ in fruit flies increased the lifespan of fruit flies. This suggests that, in humans, strong expression of OXR1 may help extend lifespan. “Our next step is to find specific compounds that delay brain aging and extend lifespan by increasing OXR1 levels,” the research team said.
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