“Dr. Anan” reveals research. Male patients if infected with “Covid-19” have more severe symptoms than female patients. Why did you read it?
Today (29 April 65) Dr. Anan Jongkaewwattana, a researcher in virology Biotech, posted a message via Facebook Anan Jongkaewwattana about the Covid-19 virus, stating that
“COVID-19 patient information Those with severe symptoms were more likely to be males than females. Especially the elderly men are more likely to be infected with coronavirus and have more severe symptoms than other age groups. This observation has been researched to find an explanation for many pieces. which supports such observations An article published in the journal Immunology sums it up quite interestingly.
Men have hormones called Androgens, consisting of testosterone and dihydrotestosterone. in high quantity While females have higher levels of estrogen and progesterone than men. This hormonal difference was found to directly affect the ability to infect the SARS-CoV-2 virus.
The hormone testosterone has an effect on increasing the expression of protein (TMPRSS2) that allows the virus to enter cells, while estrogen in women, in addition to not improving the virus’s entry into cells. It can also stimulate inhibition of ACE2 protein, a key receptor protein for viral entry into cells. This makes important organs of men such as the lungs and heart have a higher expression of ACE2 than women.
Interestingly, estrogen has also been found to play a key role in the production of a protein called TLR7 that detects viral infections more quickly and well, resulting in a better response to infection than men. The chance that the virus will multiply after it enters the body is slower.
Men also had a higher ratio of neutrophil white blood cells, which are the main culprits for severe pneumonia in coronavirus patients. There are fewer white blood cells, whether it’s B cells or T cells, than women. Overall, nature provides women with more defense mechanisms against SARS-CoV-2 infection than men on many levels.
https://onlinelibrary.wiley.com/doi/10.1111/imm.13487
picture from Anan Jongkaewwattana / AFP/ Archyde.com