2023-08-24 17:00:00
Mice fed a high-calorie diet may have escaped weight gain thanks to an experimental drug developed by scientists at the University of Texas Health and Science Center.
Eat what you want without gaining weight, soon a dream come true? This is what a team of scientists from the University of Texas Health and Science Center at San Antonio is working to develop. On Monday, August 22, the magazine Science Alert relayed a study published in Cellular reports conducted on mice fed a diet high in sugar and fatwhose intake of a test drug prevented them from accumulating fat.
Known by the chemical acronym CPACC, this experimental drug mimics the action of magnesium on the body and generating energy, and therefore, burning calories. Ultimately, this treatment could help fight obesity, diabetes and cardiovascular disease. “These experiences are the result of several years of work”says Madesh Muniswamy, a molecular biochemist at UT Health San Antonio, and co-author of the research.
A wonder drug?
Composed of calcium, potassium, sodium and magnesium, this drug helps to multiply cellular functions. Also according to scientists, Magnesium allows the body to regulate blood sugar, blood pressure and strengthen the framework.
It was by studying the deletion of a gene called Mrd2, which serves as a channel for transporting magnesium, that the team shaped this drug. When this gene is deleted, the researchers were able to observe an improvement in the health and the loss of fatty matter in the mice after fourteen weeks of treatment. “Lowering mitochondrial magnesium attenuated adverse effects of prolonged dietary stress”explains the biologist and participant in the experiment, Manigandan Venkatesan.
“Development is on its way”
Nonetheless, it is difficult to affirm that the metabolic reactions of mice are transposable to humans. The study authors also state that this chemical formula comes up against certain limitations.
However, Madesh Muniswamy remains optimistic about the experience: “This drug which can reduce the risk of cardiomeabolic diseases such as heart attacks, strokes but also that of developing liver cancer can cmake a huge step forward.” And to conclude that the development is taking its course.
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