Dietary choline appears to provide some protection against Alzheimer’s. (Image: freshidea/stock.adobe.com)
Choline in the diet reduces Alzheimer’s risk
Choline is important for many processes in the body and, according to a recent study, a sufficient intake through the diet could also be necessary Alzheimer protection.
In the new study involving experts from the Arizona State University investigated the extent to which dietary choline intake is associated with Alzheimer’s. The results are published in the journal “Aging Cell” published.
Alzheimer’s disease is increasing
In view of the sharp increase in Alzheimer’s disease worldwide, there is an urgent need for ways to reduce the risk of developing the disease. The research team has now investigated whether the choline intake about diet could play a role.
Body produces little choline
Although choline is also produced by the body itself, according to the researchers, the endogenous production by the phosphatidylethanolamine-N-methyltransferase protein in the liver is insufficient for adequate physiological functions. So be it required choline about the diet record.
The research team has now examined the effect of dietary choline intake on normal mice and on genetically modified Alzheimer’s mice. The mice were either fed a diet with sufficient choline or ate a diet without choline.
consequences of choline deficiency
It was shown that when there was a lack of intake through the diet, the choline level in the blood dropped, the weight of the mice increased and both motor functions and glucose metabolism were impaired, with the effect being more pronounced in the Alzheimer’s mice.
According to the researchers, an analysis of the tissue of the mice finally revealed damage to the liver as well as one enlargement of the heart established. The team also identified increased soluble, oligomeric and insoluble Amyloid-beta-Proteine in the animals.
Additionally there was Changes in tau proteincharacteristic of the emergence of so-called neurofibrillary tangles are in the brain, explains the team. Malfunctions of the tau protein and neurofibrillary tangles or corresponding deposits in the brain are associated with a number of neurodegenerative diseases related, including Alzheimer’s and other forms of dementia.
Further analyzes then showed that a lack of choline in the diet Networks in the hippocampus altered ones associated with microtubule function and regulation of the postsynaptic membrane.
In addition, the lack of choline in the blood plasma changed protein networkswhich are linked to insulin metabolism, mitochondrial function, inflammation and processing of fructose, the team explains.
Make sure you have enough choline in your diet
In view of the test results, the experts point out that people with an increased Alzheimer-Risk and people already attending Alzheimer’s disease are, you should definitely pay attention to enough choline about their Nourishment record.
food that lots of choline included are for example:
- Owner,
- Meat,
- Dairy products,
- Fisch,
- Nuts,
- Together,
- soybeans,
- beans,
- Lenses,
- Whole grain products,
- Vegetables.
In summary, according to the researchers, it can be said that a sufficient uptake of choline about the diet is needed to systemic organ pathologies (diseases that affect multiple organs or the entire body system) and those for Alzheimer’s characteristic disorders to reduce. (as)