Germany developed a new multifunctional film dressing caused by mucin! Effectively accelerate wound healing and inhibit inflammation | GeneOnline News

A research team from the Technical University of Munich (TUM) in Germany has developed a new type of film dressing using mucins molecules, which can not only protect wounds like ordinary dressings, but also add active drugs to accelerate wound healing, expel bacteria, Inhibits inflammation, and finally decomposes on the skin by itself, which is a new gospel for sensitive skin.

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Versatile dressing for sensitive skin surfaces

Although traditional dressings are very effective for the protection and treatment of small wounds, it is difficult to deal with wounds such as the tongue or sensitive tissues. For this reason, Oliver Lieleg, professor of biomechanics at the Technical University of Munich, led his research team to develop biological Film dressings composed of polymers are expected to optimize the situation of wound repair in sensitive tissues.

According to the research team, the film dressing is flexible when dry and can be easily picked up and placed on the wound with tweezers; once it touches the wet wound tissue, its bottom will become soft, soft and sticky. Self-adhering to wound tissue without external bandage fixation. In addition, film dressings can cover and protect wounds, whether it is a smooth surface of cartilage tissue or a moist area such as the tongue.

The film dressing newly developed by the University of Munich in Germany has the functions of anti-inflammatory, anti-bacterial infection and accelerated wound healing. (Image credit: Ceren Kimna, TUM, University of Munich, Germany)

Double-layer film material, effectively accelerate wound healing

The composition of the film has two layers. The upper layer is composed of mucin polymers naturally present in the human body, which can stabilize and biodegrade the film. It also has antibacterial properties and effectively inhibits inflammation. The lower layer contains hyaluronic acid (hyaluronic acid), Using its ability to bind water molecules to promote wound healing, and to interact with other chemical molecular materials, the monolithic dressing can be made moist and sticky to adhere to the tissue. In addition, active pharmaceutical ingredients such as antibiotics can also be added to the lower layer to accelerate wound healing.

Biodegradable film dressings made from freeze-dried mucin. (Image credit: Astrid Eckert, TUM, University of Munich, Germany)

At present, the research team has studied the protective effect of this new film dressing in various animal tissue samples. In the future, the material will be optimized according to specific tissue types, so that it can be used in clinical operations to temporarily protect internal wounds.

Further reading: Anti-sticking! Prevent infection!New photocurable hydrogel has good effect on postoperative wound repair

References:
1. https://www.tum.de/en/about-tum/news/press-releases/details/37410
2. https://onlinelibrary.wiley.com/doi/10.1002/adfm.202105721