2023-12-05 01:47:34
Delivery time2023-12-05 10:47
(Seoul = Yonhap News) Reporter Han Seong-gan = A study has shown that if a lesion is found on the cervix, it is more advantageous to immediately remove it rather than leaving it as is and actively monitoring it.
Cervical lesions are intraepithelial neoplasia (CIN), which refers to abnormal changes in the lining cells of the cervix. CIN is classified into grades 1 to 3, and as the grade increases, the risk of progression to cancer increases.
CIN is not cancer, but if left untreated, abnormal cells can turn into cancerous cells. CIN grade 2 is a borderline that determines whether abnormal cells should be removed. Studies have shown that 50 to 60% of CIN grade 2 cases recover spontaneously within 2 years.
There are concerns that immediate resection of cervical lesions may be overtreatment. In particular, resection of grade 2 CIN may increase the risk of premature birth in later pregnancies.
Therefore, in many countries, ‘active surveillance’ is recommended for relatively young women with CIN level 2.
However, as a result of a 20-year follow-up study conducted by Dr. Anne Hammer, an obstetrician and gynecologist at the Department of Clinical Medicine at Aarhus University Medical School in Denmark, on 27,524 women whose cervical lesions were discovered between 1998 and 2020, HealthDay News reported on the 4th that ‘moderation’ was found to be much more advantageous.
Of these, 12,483 (45%) chose ‘active surveillance’ and 15,041 (55%) immediately underwent large loop excision of the lesion site.
‘Active surveillance’ involves monitoring to ensure that abnormal cells do not spread further through periodic examinations for two years after the lesion is discovered.
There was no significant difference in the incidence of cervical cancer over the first two years, at 0.56% in the ‘active surveillance’ group and 0.37% in the ‘immediate resection’ group.
However, after that, in the ‘active surveillance’ group, the cervical cancer diagnosis rate began to increase, rapidly rising to 2.65% 20 years later. This is nearly four times higher than the 0.76% in the ‘immediate resection’ group. This risk occurred mainly in women over 30 years of age.
The research team explained that this may be because, in the case of women in the ‘active surveillance’ group, the human papilloma virus (HPV), which causes cervical cancer, was latent in abnormal cells and became active as immunity weakened with age.
The results of this study were published in the latest issue of the British Medical Journal (BMJ).
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