2023-08-18 15:50:00
Another recently published review by the German Cancer Research Center is now dedicated to the influence of vitamin D supplementation on various inflammatory markers in patients with cancer or precancerous lesions. High levels of inflammation, like low vitamin D levels, are associated with higher cancer mortality [1].
Influence on TNFα , IL-6, CRP and IL-10
For their review, the researchers evaluated eight randomized, controlled studies with a total of 592 participants. They had either received vitamin D3 supplements or placebo. A statistically significant reduction was observed in serum levels of tumor necrosis factor (TNF)-α. The serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) also decreased under the supplementation of vitamin D3. Statistical significance was not reached here. The interleukin-10 levels also examined did not differ between the verum and placebo arms.
The question of the mechanism by which vitamin D influences the formation of these inflammatory markers has not yet been clarified. A vitamin-dependent expression of certain genes in some body cells is conceivable. For example, mechanistic studies indicate that vitamin D downregulates the expression of NF-kB (transcription factor) via vitamin D receptors [1].
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