Research has found that inhaled aerosol vaccines provide much stronger immunity than nasal sprays.
Nasal sprays mainly reach the nose and throat. On the other hand, inhaled aerosols can bypass the nasal passages and deliver vaccine droplets deep into the airways, inducing a broad protective immune response.
Researchers at McMaster University in Canada used a tuberculosis vaccine to measure the distribution of droplets, immune responses, and efficacy in animals to compare delivery methods, published by the American Association for the Advancement of Science’s eurekalert. .
When the vaccine was delivered directly to the lungs, it stimulated a stronger immune response, making it much more effective against tuberculosis (TB).
“The immune response that occurs when a vaccine is delivered deep into the lungs is more responsive than when the substance is deposited in the nose and throat because of the anatomy and nature of the tissue,” said Miller, a researcher at Global Nexus for Pandemics & Biological Threats in Canada. “It’s very strong and the immune cells that can respond are also different,” he said.
“This study provides for the first time strong preclinical evidence supporting the development of inhaled aerosol delivery for human vaccination against respiratory infections, including tuberculosis, COVID-19 and influenza,” said co-author and Professor Zhou Xing, McMaster Immunology Research Center. provided by it.”
The world is in a desperate new effort to develop a vaccine that can be delivered directly to the mucous lining of the respiratory tract after COVID-19.
The McMaster University research team hopes that the inhaled coronavirus vaccine will provide the best defense against the epidemic. Currently, a phase 1 clinical trial is underway to evaluate an inhaled aerosol vaccine in healthy adults who have received two or three doses of the COVID-19 mRNA vaccine.
In addition, the research team expects that the inhaled vaccine will achieve the maximum effect with a much smaller dose than the existing injectable vaccine because it is very effective in targeting the lungs and upper respiratory tract in addition to the fact that there is no pain in inoculation compared to the existing vaccine.
Reporter Jang Bom-i [email protected]
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