Strong link between gut microbiome and metabolites
According to a recent study, there is a close connection between the bacteria living in the gut and the metabolic products present in the bloodthe so-called metabolites. The discovered relationships open up new insights into the interactions between the Darmflora and their host.
researchers of Uppsala University and the Lund University in Sweden have shown in a recent study that the metabolites in the blood are partly dependent on the composition of the intestinal flora. The results were recently published in the renowned journal “Nature Communications“ published.
Over 8,500 stool and blood samples analyzed
The scientists involved analyzed for the research work stool and blood samples of 8,583 subjects who took part in the so-called CArdioPulmonary bioImage Study (SCAPIS).
The SCAPIS study is one of the world’s largest collections which contains both blood and stool samples from participants.
Intestinal bacteria release metabolic products into the blood
“Previous studies have shown that the large bacterial community in our digestive system produces a variety of molecules that can enter the bloodstream and affect our health”explained Professor Tove Fall vom Science for Life Laboratory der Uppsala University.
An important step in understanding the intestinal flora
“Conversely, drugs or dietary components can affect the composition of the microbiota before they enter the bloodstream”gives case to consider.
According to her, characterizing these interactions is an important step in order to Effects of gut microbiota on health to understand.
The intestinal flora is a universe of its own
“The gut microbiota is a universe unto itself, and we are only just beginning to understand how the human host and the bacterial community interact”added Professor Marju Orho-Melander from Lund University.
According to her, the study results show that the intestinal bacteria play an important role for certain blood metabolites. But which metabolic products have which exact tasks and effects in the body must first be examined in future studies.
“The large number of samples with high quality data allowed us to identify many new associations”study lead author emphasizes Koen Dekkers out.
Study results freely available for other research groups
Therefore, the working group presented the study results in a freely accessible Online-Atlas, which can be used by other research groups. In this way, the team wants to help clarify the extent to which Microbiome in the gut influences our health.
The team believes that the breadth of the results could spark the interest of other international groups studying the gut microbiota and host-organism interactions. (vb)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Author:
Graduate editor (FH) Volker Blasek
Sources:
- Dekkers, K.F., Sayols-Baixeras, S., Baldanzi, G. et al. An online atlas of human plasma metabolite signatures of gut microbiome composition; in: Nature Communications (2022)., nature.com
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.