Microorganisms in the stool of a child patient transplanted into mice…
One of the causes of Autism Spectrum Disorder (ASD), which is attracting attention due to the explosive popularity of the drama ‘Strange Lawyer Woo Young-Woo’, is a research result that the gut microbes are.
This is the result of a study conducted by a joint research team at the University of Rome and the University of Calabria in Italy transplanting intestinal microbes from autism spectrum patients into mice. The team transplanted gut microbes from feces donated by autistic spectrum disorder patients into mice, and found that gut microbes were closely related to social behavior typical of autism spectrum disorder. Pathways between the gut microbiota and the central nervous system may adversely affect social behavior, one of the most characteristic symptoms of the autism spectrum. So far, the main causes of the autism spectrum have not been clearly identified. However, according to the results of previous studies, the autism spectrum may be caused by the interaction of certain genes and environmental factors.
The research team performed ‘fecal microbiota transplantation (FMT)’, in which the intestinal microbes of children with autism spectrum disorder were transplanted into mice through gavage, and then conducted a maze experiment and analyzed the microbes in the mice’s stomachs. Mice transplanted with gut microbes from children with autism spectrum disorder showed strange behavior in the maze experiment, and showed a marked increase in the tenericutes flora in the gastrointestinal tract and a marked decrease in Actinobacteria and Candidatus. In addition, mice that received the microbes transplanted showed significantly more various inflammatory factors in the brain and small intestine than mice that did not (control).
The researchers said further studies in patients with autism spectrum disorder are needed before manipulating the gut microbiome with an appropriate diet or probiotics. The results of this study (Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism) were published in the journal Neuroscience and were introduced by the American health medicine media, ‘MedicakXpress’.
On the other hand, as a result of a study (2017) conducted by a joint research team of four universities including Arizona State University in the United States on 18 autistic patients aged 7 to 16 years, treatment with gut microbiota reduced digestive system symptoms in autistic patients by about 80%, and social behavior and social behavior. It has been shown to improve sleep habits by 20-25%, respectively.
By Kim Young-seop, staff reporter [email protected]
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