Link between migraines and type 2 diabetes explained

The results of a study conducted by scientists from the University of Tennessee (USA) will presented during the next conference of the American Chemical Society.

A relationship between migraines and type 2 diabetes has been noted in a number of previous studies. However, why the risk of diabetes is reduced with migraines, and vice versa, was still unclear.

As previously established by Thanh Do and colleagues, two substances (neuropeptides) – CGRP and PACAP – not only act on the nervous system, playing a key role in the development of migraine pain, but are also present in the pancreas, affecting the production of her cells of the hormone insulin. Scientists do not exclude that neuropeptides regulate the volume of insulin released into the blood and even increase the number of hormone-producing cells in the pancreas.

Thus, migraine patients are protected from diabetes due to the increased activity of CGRP and PACAP. Conversely, diabetic patients are less prone to migraines due to the low activity of these neuropeptides.

However, the researchers note, it is not yet possible to directly use CGRP and PACAP to treat diabetes, since the introduction of these substances into the body will increase the risk of migraines. Therefore, the development of analogs of neuropeptides, which would regulate the production of insulin, but do not bind to pain receptors, remains to be developed. In addition, Do and his colleagues are concerned that already developed and marketed anti-migraine drugs based on lowering the activity of CGRP and PACAP may increase the risk of diabetes.

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