2024-02-13 23:54:31
(From left) Seoul National University Bundang Hospital Gastroenterology Professor Nayoung Kim, Senior Researcher Sooin Choi, Researcher Ryeonghee Nam, and Professor Lee Dongho
[헬스코리아뉴스 / 이지혜] A microbial strain effective in treating ‘irritable growth syndrome’, which many modern people suffer from, was discovered, and its gender-specific effects were also identified.
The research team of Professor Na-young Kim and Professor Dong-ho Lee of the Department of Gastroenterology at Seoul National University Bundang Hospital focused on the effectiveness of transplanting beneficial bacteria extracted from healthy intestines into the intestines of patients with irritable bowel syndrome and conducted research to find suitable strains.
The research team confirmed that the ‘Roseburia Faecis’ strain observed in healthy donors had an excellent anti-inflammatory effect and administered it orally for 13 days to a mouse model that caused symptoms similar to diarrhea-type irritable bowel syndrome. Changes in environment and defecation were observed.
When Roseburia paesis was administered to mice suffering from irritable growth syndrome-like symptoms (WAS, middle bar) (WAS+R22-12-24, right bar), the number of mast cells that worsened irritable growth syndrome symptoms was significantly reduced. This trend was most noticeable in male (blue) mice.
As a result, when Roseburia paesis is administered orally, the number of ‘mast cells’, which are distributed in the intestinal mucosa and submucosa, increase in number when exposed to stress, and increase the severity of irritable bowel syndrome such as abdominal pain, is greatly reduced and diarrhea symptoms are reduced. This appeared to be improving. In particular, it was confirmed that this effect was significant in male mice.
When the bacterial flora of feces was analyzed, the expression of genes related to the absorption of essential amino acids returned to normal, and the collapsed homeostasis (the tendency of organisms to stably maintain an optimal state) was shown to be restored. This was also a noticeable phenomenon in male rats.
The research team explained that the results of this study suggest that Roseburia paresis strains derived from healthy intestines have high potential as probiotics (live microorganisms that have beneficial effects when administered into the body) that can treat diarrhea-type irritable bowel syndrome. .
Professor Na-young Kim said, “We were able to confirm that not only the therapeutic effect of the Roseburia paresis strain, but also the gender difference between men and women should be considered when selecting probiotics.” He added, “Based on the results of this animal test, we will conduct clinical trials on humans in the future to enable a large number of modern people. “We will find a clue to solving hyperactive growth syndrome, which reduces the quality of life of people.”
This study was conducted with support from the Ministry of Trade, Industry and Energy, and was recently published in the international academic journal ‘Journal of Cancer Prevention’.
What is irritable bowel syndrome?
Irritable Bowel Syndrome refers to a set of chronic symptoms that mainly cause abdominal pain and discomfort after eating and abnormal bowel habits such as diarrhea or constipation without any special disease or anatomical abnormality.
Irritable growth syndrome, which is common enough to affect about 10% of all Koreans, can easily be misunderstood as a condition that causes stomach pain when nervous, but in reality, the decline in quality of life suffered by patients is serious. Patients experience constant abdominal pain and rapid diarrhea throughout their lives, which greatly interferes with their studies and work life, and they complain of difficulties in daily life, such as driving long distances or using public transportation.
Factors such as stress, inflammation, gut-brain nervous system disorders, and intestinal bacterial imbalance have been pointed out as factors that increase the prevalence and worsen symptoms of irritable bowel syndrome. However, nothing is known about the mechanism of occurrence and there is no clear treatment.
The video below is an explanation video by Professor Shin Seong-jae of the Department of Gastroenterology at Ajou University Hospital on irritable bowel syndrome.
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