On January 2, Prof. Dr. Yong Phuworawan, the head of the center specializing in virology Clinic, Department of Pediatrics Faculty of Medicine Chulalongkorn University Has posted a message on his personal Facebook page “Yong Poovorawan” on the issue of Covid 19, vaccine, 3 needle stimulation in various formulas of Thailand. by specifying The triple booster vaccine uses mRNA and virus vectors such as Pfizer (PZ), Modena (MN), AstraZeneca (AZ).
Today, I will show you information about mRNA activation in various formulas in Thailand that are used, such as 2 injections of dead germ SP-SP, SV-SV, SV-AZ, AZ-AZ, which are the main formulas used in Thailand. This was a clinical study with a detailed record of adverse effects. and requiring that getting the 2nd needle must be away from the 3rd needle stimulation at 5-7 months, all patients over 18 years of age are in good health The limitation of this study was that the age group of AZ-AZ was higher than other groups according to the actual situation in Thailand. The study will test pre-injection blood, after 2 weeks and 4 weeks, and plan to follow up at 90 days after the 3rd injection.
The use of mRNA vaccine in Thailand is mainly used as a booster. because a large number of other vaccines have been vaccinated The AZ actuation part of the SV-SV-AZ group has been published, while the SV-AZ-AZ and AZ-AZ-AZ will be presented next. already injected into volunteers
Moderna used as a stimulant in America. Only half the dose is given, either as a booster after vaccination with Pfizer Moderna or J&J vector virus.
Similarly, the United Kingdom uses a half-dose booster dose of Moderna, followed by AZ. to reduce the side effects that occur It can be seen that the most common side effects are pain at the injection site, inability to raise the arm, aches and pains in the body, headache, vomiting, diarrhea, and most importantly, in the stimulation needle. will find enlarged lymph nodes under the arm More than needles 1 and 2 (US CDC data)
Therefore, half-dose studies were also conducted. The preliminary data present here are two measures of immunity: total immunoglobulin per RBD in unit/ml, and specific IgG per RBD of sprite protein in BAU/ml.
Education in Thailand by the Chula Clinical Virology Specialist Center that is doing it, showing that the stimulation needle Whether after 2 doses of inactivated vaccine SV-SV, SP-SP, SV-AZ, AZ-AZ, as shown in the figure.
The stimulating effect is high immunity. In both tests, they were consistent, ie with prior exposure to SV-SV, the stimulation had the highest immunity, higher than that of SP-SP, SV-AZ. resistance equal to AZ-AZ
However, if looking at the immunity level, all groups were still at a high level.
Currently collecting PZ-PZ-PZ 3 needles (triple P) in Thailand for comparison. (now got a certain number) and is studying AZ-AZ-AZ, also known as triple A, to get information on all groups that are used in Thailand, while the MN-MN-MN group or triple M would be rare or have to wait a long time
Half-dose mRNA, especially MN, did not differ significantly from full-dose parallelism. because the landscape is very high and obviously less side effects
The level of neutralizing antibody (NT) immunity against different species. A fair amount of work has been done using sVNT or artificial and real viruses, Delta and Omicron strains (the virus is now isolated from the patient). and has been done in part by Professor Jutathip et al at Siriraj) and CMIR cellular reactions have been partially carried out. will be shown in the next opportunity as well as collecting white blood cells to be studied in depth further
In the past, education at the level of immunity There is a good relationship with sVNT in different species. as has been published in international journals
such information It will continue to be published in foreign journals. And it will be very beneficial to manage vaccines in Thailand appropriately and for the most benefit for Thailand. by education in Thailand rather than using data from foreign countries And at the same time it is necessary to study from real situations. to the effectiveness of disease prevention