2023-08-25 17:00:00
“Current genetic tests for breast cancer only take into account a few high-risk genes, such as BRCA1, BRCA2 and PALB2. However, these genes explain only a minority of the genetic risk, which suggests that other genes still need to be identified”, explain Canadian (Laval University) and British (Cambridge University) researchers.
An important discovery
Which conducted a study to highlight four new genes associated with the risk of breast cancer. And this by analyzing the genetic modifications of 26,000 women with breast cancer and 217,000 women without the disease.
“Although most of the new genetic variants identified are rare, the risks can be significant for women who carry them,” says Professor Jacques Simard, researcher at the genomics center of the CHU de Québec-Université Laval research center.
“For example, alterations in one of these novel genes, MAP3K1, appear to predispose to a particularly high risk of breast cancer.”
For the authors, this discovery should provide crucial information on the biological mechanisms underlying the development of cancer, thus opening the way to new forms of screening, but also to new therapeutic targets.
Source : Nature Genetics
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