2023-05-07 10:30:00
A family history — that is, whether a mother or sister has polycystic ovary syndrome (PCOS) — puts a woman at a 30% increased risk of developing the disease, according to theHealth Insurance. But it would seem that men also have to fear a genetic factor with this pathology. According to a study published in the journal Cell Reports Medicinesons of patients with PCOS are three times more likely to develop obesity.
PCOS: it promotes diabetes, cholesterol and obesity
PCOS is caused by a hormonal imbalance characterized by excessive production of certain hormones, especially testosterone. This syndrome can be manifested by irregular periods, hyperpilosity, acne, hair loss, or by the presence on the ovaries of a very large number of follicles with incomplete development, a source of infertility. The disease is also associated with an increased risk of developing certain health problems such as type 2 diabetes or cholesterol for patients. But that’s not all :
“We found that the sons of women with PCOS have a threefold increased risk of obesity and high levels of “bad” cholesterol, which increases [aussi] the risk of developing insulin resistance and type 2 diabetes later in life“, explains Elisabet Stener-Victorin, who led the study, in a communiqué.
During their work, the researchers conducted experiments on mice. The females were treated with hormones to develop PCOS-like conditions during pregnancy. Their male offspring were then studied by scientists. “We were able to see that these male mice had more adipose tissue, larger fat cells and a disordered basal metabolism, despite eating a healthy diet.”explains Elisabet Stener-Victorin.
PCOS: consequences that can impact up to 3 generations
From these male rodents, scientists studied the impact of PCOS over several generations. Thus, they observed the same results up to three generations. “High levels of male hormones [la testostérone] in women during pregnancy could cause long-term health problems in male offspring, says Qiaolin Deng, one of the authors. Their fatty tissue, metabolism and reproductive function deteriorate, which then affects future generations.”
As of now, there is no cure for PCOS. The only solutions offered to patients aim to reduce symptoms and induce ovulation if pregnancy is desired.
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