Rise of the XFG Variant Fuels New COVID-19 Wave in France

September 25, 2025

COVID-19 Cases Surge as new Variant Gains Ground

A resurgence of Covid-19 is currently underway, coinciding with the start of the school year and the onset of colder temperatures. Public health officials are reporting a notable increase in respiratory illnesses, including coughs, bronchiolitis, and common ENT infections, alongside a renewed climb in Covid-19 infections. The latest data suggests a sustained rate of transmission, prompting renewed calls for preventative measures.

Increase in Hospitalizations and Emergency Visits

Recent statistics indicate a significant rise in covid-19 related hospitalizations and emergency room visits. During the week of September 15th to 21st,2025,hospitalizations among adults increased by 37%,representing an additional 375 cases. While early data suggests a slight decline in cases among children, overall numbers remain a cause for concern.

The Return of SARS-CoV-2

This renewed wave of SARS-CoV-2, which has been building for several weeks, is confirmed by the sentries network, a French institution dedicated to public health research and primary care surveillance. The data from september 15th to 21st, 2025, shows an impact rate of 49 cases of Covid-19 per 100,000 inhabitants, totaling 32,610 new cases – a rise from the 26,053 cases reported the previous week. This increase in infection rates is notably prominent among individuals aged 15 to 64, with over 22,000 new cases recorded compared to 14,901 the week prior.

A Highly Contagious Variant: XFG

Experts attribute this upswing to the prevalence of the XFG variant, frequently enough dubbed “Stratus” by scientists, due to its heightened contagiousness. The World Health Organization first flagged the emergence of this Omicron sub-variant in June, noting that mutations within the Spike protein enhance its ability to evade existing antibodies.

This variant, also referred to as “frankenstein” by some, is now dominant, accounting for over 80% of infections in Europe, according to the European Centre for Disease Prevention and Control.Despite its increased transmissibility,the variant does not currently appear to cause considerably different symptoms compared to previous strains. Common symptoms include upper respiratory tract infections, fatigue, and headaches, with some individuals experiencing a loss of taste or smell.

protecting Vulnerable populations

While symptoms are generally mild, complications can occur in individuals with compromised immune systems, including the elderly, infants, pregnant women, and those with underlying health conditions. Public health officials stress the importance of maintaining preventative measures, such as practicing good hygiene and wearing FFP2 masks in poorly ventilated spaces.

The upcoming Covid-19 and influenza vaccination campaign, scheduled to begin on October 14th (excluding mayotte), is also considered crucial. Experts recommend booster shots for vulnerable individuals as a precautionary measure. It is indeed anticipated that this wave of infections will not reach the levels seen in previous years, and will be significantly less severe than the initial stages of the pandemic.

Metric	September 15-21, 2025	Previous Week	Change
Adult Hospitalizations	375 cases	0 cases	+37%
New COVID-19 Cases	32,610	26,053	+25%
New Cases (15-64)	22,000+	14,901	+47.6%
XFG Variant Prevalence	80%+	N/A	N/A

Did You Know? A recent study by the CDC showed that updated COVID-19 boosters provide significant protection against currently circulating variants.

Pro Tip: Maintaining good ventilation indoors, alongside vaccination and masking, can dramatically reduce your risk of infection.

Are you prepared for the potential resurgence of Covid-19 this fall? What steps will you take to protect yourself and your community?

Understanding Covid-19 Variants

Viruses, including SARS-CoV-2, are constantly evolving. Mutations can lead to new variants with altered characteristics, such as increased transmissibility or immune evasion. Staying informed about the latest variants and their potential impacts is crucial for public health preparedness.

The XFG variant, while highly contagious, doesn’t appear to cause more severe illness overall. though, its ability to circumvent immunity gained from previous infections or vaccinations underscores the importance of staying up-to-date with booster shots.

Frequently Asked Questions about COVID-19

• What are the common symptoms of the current COVID-19 variant? Common symptoms include fever, cough, fatigue, headache, sore throat, and loss of taste or smell.
• Is the COVID-19 vaccine still effective? Yes, vaccines continue to provide strong protection against severe illness, hospitalization, and death. Booster shots are recommended to maintain optimal immunity.
• what can I do to protect myself from COVID-19? practice good hygiene, wear a mask in crowded or poorly ventilated spaces, get vaccinated and boosted, and stay home if you’re feeling sick.
• How is the XFG variant different from previous strains? The XFG variant has mutations that allow it to evade antibodies more effectively, making it more contagious.
• Are children at higher risk from the current COVID-19 surge? While children are generally less likely to experience severe illness, they can still be infected and transmit the virus.
• When should I get tested for COVID-19? You should get tested if you experience any symptoms of COVID-19 or have been in close contact with someone who has tested positive.
• Where can I find more facts about COVID-19? You can find reliable information from the World Health Organization and Centers for Disease Control and Prevention.

Share this article with your network to help keep others informed. Leave a comment below with your thoughts on the current situation.

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Understanding the XFG Variant

The emergence of the XFG variant is currently driving a significant increase in COVID-19 cases across France.First detected in late August 2025, XFG is a subvariant of Omicron, exhibiting characteristics that are raising concerns among public health officials. Initial genomic sequencing suggests increased transmissibility compared to previous strains, alongside a potentially reduced sensitivity to existing immunity – both from prior infection and vaccination. This means individuals previously protected may be more susceptible to reinfection.

* Key Characteristics of XFG:

* Higher R0 (basic reproduction number) – indicating faster spread.

* Mutations affecting the spike protein, potentially impacting antibody neutralization.

* Preliminary data suggests a slightly longer incubation period (averaging 4-6 days).

* Dominant symptoms appear similar to previous Omicron variants,but with a reported increase in upper respiratory tract involvement.

Current Situation in France: Case Numbers and Regional impact

As of September 25, 2025, France is experiencing a marked surge in COVID-19 cases.The national incidence rate has climbed to[InsertCurrentIncidenceRate-[InsertCurrentIncidenceRate-Data to be updated at publishing]per 100,000 people, a[InsertPercentageIncrease-[InsertPercentageIncrease-Data to be updated at publishing]increase compared to the beginning of September.

* Regional hotspots:

* Île-de-France (Paris region) is currently the most affected area, with hospitalizations increasing by[InsertPercentage-[InsertPercentage-Data to be updated at publishing]in the last two weeks.

* Auvergne-Rhône-Alpes is also experiencing a significant rise in cases, notably among unvaccinated individuals.

* Brittany and Normandy are showing early signs of increased transmission.

Hospitalization rates are rising, but remain below peak levels seen in previous waves. However, health authorities are closely monitoring the situation, particularly the number of patients requiring intensive care. The strain on the healthcare system is a major concern, especially with the onset of the seasonal flu.

Symptoms of the XFG Variant: What to Watch For

While symptoms associated with the XFG variant are largely consistent with previous COVID-19 strains, some subtle differences have been observed.

* Common Symptoms:

* sore throat

* Runny nose

* Cough

* Fatigue

* Headache

* Muscle aches

* Less Common,but Reported Symptoms:

* Loss of smell or taste (less prevalent than with earlier variants)

* Gastrointestinal issues (nausea,vomiting,diarrhea)

* increased reports of conjunctivitis (pink eye)

It’s crucial to remember that symptom presentation can vary substantially between individuals. If you experience any of these symptoms, especially if you are at high risk, it’s essential to get tested for COVID-19.

Vaccination and Booster Effectiveness Against XFG

Current COVID-19 vaccines continue to offer protection against severe illness, hospitalization, and death from the XFG variant. However,their effectiveness against infection is reduced.

* Booster Dose Recommendations:

* French health authorities strongly recommend that all eligible individuals receive a booster dose of an updated COVID-19 vaccine.

* Priority is being given to individuals aged 65 and older, those with underlying health conditions, and healthcare workers.

* The updated vaccines are designed to target current circulating variants, including XFG, and provide broader protection.

* Vaccine Efficacy Data (Preliminary):

* Studies suggest that a booster dose increases protection against symptomatic infection with XFG by approximately[InsertPercentage-[InsertPercentage-Data to be updated at publishing].

* Vaccination remains highly effective in preventing severe outcomes, even with breakthrough infections.

Testing and Treatment Options for COVID-19

Testing

Accessible and rapid testing remains a critical component of managing the XFG wave.

* Available Testing Methods:

* PCR tests (considered the gold standard for accuracy)

* Rapid antigen tests (convenient and provide results within 15-30 minutes)

* Self-tests (available for home use)

* where to Get Tested:

* Pharmacies

* Laboratories

* Testing centers

Treatment

For individuals who test positive for COVID-19, several treatment options are available, depending on the severity of the illness and individual risk factors.

* Mild to Moderate Cases:

* rest and hydration

* Over-the-counter medications to relieve symptoms (pain relievers, fever reducers)

* Severe Cases (Hospitalized Patients):

* Antiviral medications (e.g., Paxlovid, Remdesivir) – can help reduce viral load and shorten the duration of illness.

* Monoclonal antibody treatments (effectiveness against XFG is currently being evaluated).

* Supportive care (oxygen therapy, mechanical ventilation)

Public Health Measures and Prevention Strategies

To mitigate the spread of the XFG variant, French authorities have implemented several public health measures.

* Recommended Precautions:

* Wearing masks in crowded indoor settings.

* Practicing good hand hygiene (frequent handwashing with soap and water