Risk of gout more than doubled in young men with metabolic syndrome

Even young men with metabolic syndrome have been shown to have an increased risk of gout.

Sungkyunkwan University School of Medicine Gangbuk Samsung Hospital Rheumatology Professor Eun Young-hee, Samsung Seoul Hospital Lee Jae-joon and Kim Hyung-jin research team analyzed the relationship between the presence of metabolic syndrome and gout in men in their 20s and 30s and published it in the American Journal of Rheumatology (Arthritis & Rheumatology).

Metabolic syndrome is a case of having three or more of hypertension, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol, and abdominal obesity, and is well known as a risk factor for diabetes, fatty liver, and cardiovascular disease.

According to the research team, it is known that gout patients are rapidly increasing in young men recently, but there are few studies on gout risk factors.

The subjects of this study were 3.56 million males between the ages of 20 and 39 among health checkups between 2009 and 2012. They were divided into groups with and without metabolic syndrome, and the relevance of gout was compared and observed for 7.4 years.

As a result, the risk of gout was 2.4 times higher in patients with metabolic syndrome. Among metabolic syndrome factors, hypertriglyceridemia and abdominal obesity were highly correlated. The number of metabolic syndrome factors was proportional to the risk of gout.

In addition, compared to those without metabolic syndrome, those with chronic metabolic syndrome had an approximately four-fold higher risk of gout.

The risk of gout increased more than twice in people with new metabolic syndrome, while it was reduced by almost half when it disappeared.

“Metabolic syndrome is an important risk factor for gout in young men,” Professor Eun said. “To prevent gout, metabolic syndrome should be actively managed.”

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