Scientists have noticed that the level of menin in the hypothalamus, but not in astrocytes or microglia, decreases with age. A group of researchers decided to investigate the level of this reduction in laboratory mice. They found that loss of menin in young mice leads to increased hypothalamic neuroinflammation, including reduced bone mass and skin thickness, and cognitive decline and a moderate reduction in life expectancy.
Another change caused by the loss of the menin there was a decrease in the level of the amino acid D-serine (This acid is a neuromodulator that regulates the activity of neurons. — Note. ed.).
