2024-05-16 06:32:02
2024-05-16
SATT Conectus indicators a licensing choice with Spiklmm for the event of a prophylactic remedy towards the BK virus, a virus that causes critical issues in transplant sufferers.
Paris, France, April 16, 2024 – SpikImm, a clinical-stage biotechnology firm based in 2021 by Truffle Capital in collaboration with the Pasteur Institute and devoted to the event of monoclonal antibodies to forestall viral infections in immunocompromised sufferers, in the present day publicizes the signing with SATT Conectus of an unique collaboration and license settlement for potent monoclonal antibodies directed towards the BK virus. These monoclonal antibodies had been developed as a part of the HuMABK mission led by Prof. Samira FAFI-KREMER, Director of the Strasbourg Institute of Virology and Prof. Pascal POIGNARD, Head of the “Antibodies and Infectious Illnesses” analysis staff on the Institute of Structural Illnesses. Biology (Grenoble). This settlement strengthens SpikImm’s portfolio and experience for the prophylactic remedy of viral infections in immunocompromised sufferers.
BK virus (BKV) infects most people throughout childhood and often stays latent within the physique with out inflicting illness. Nonetheless, throughout immunosuppressive remedy, particularly in transplant sufferers, BKV can reactivate and replicate within the urinary tract, resulting in doubtlessly critical issues. In kidney transplant recipients, BKV reactivation can result in graft loss and enhance the danger of bladder most cancers. As well as, BKV is chargeable for extreme hemorrhagic cystitis in bone marrow transplant recipients. There are at present no antiviral therapies or vaccines particular for BKV. There’s subsequently an pressing medical must develop new anti-BKV prophylactic remedies.
Because of the work of Professor FAFI-KREMER, Director of the famend Institute of Virology in Strasbourg, and his staff, the important thing position of anti-BKV neutralizing antibodies in safety towards BKV an infection and related illnesses has been highlighted. Based mostly on this data, Prof. FAFI-KREMER and Prof. POIGNARD joined forces to develop monoclonal antibodies that neutralize BKV as a part of the HuMABK mission, funded by ANR and SATT Conectus. The experience of Professor POIGNARD and his collaborators on the Grenoble Institute of Structural Biology in antibody discovery has made it doable to efficiently isolate human monoclonal antibodies that neutralize BKV with a broad spectrum. These monoclonal antibodies characterize promising candidates for future medical improvement.
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