“Systematic Screening for Lung Cancer in Women: Cascade Study Delivers Alarming Results for Smokers”

2023-05-31 19:56:00

Women smokers are more affected by lung cancer than men. – Credit:SIGRID OLSSON / AltoPress / PhotoAlto via AFP

Lance by the Public Assistance-Hospitals of Paris (AP-HP), the study Cascade (Screening for Lung Cancer in French Women by Low-Dose CT Scan) delivers, a year later, its first results, which are worrying for smokers. A year ago, the High Authority of Health (HAS) recognized the value of such an approach. 3,000 female smokers or ex-voluntary smokers aged 50 to 74 have already contacted the authors of this pilot study funded by Inca and the Ministry of Health and 1,300 have been integrated, 85% of whom are active smokers.

In the end, the cohort will be made up of 2,400 volunteers, i.e. twice as many women as in the mixed NELSON study published in 2020 involving more than 15,000 volunteers but made up of an overwhelming majority of men. Review of the details of the first results with Professor Marie-Pierre Revel, head of the radiology department at Cochin Hospital, principal investigator of the Cascade study, still looking for volunteers.

Point : What are the first data from your study on systematic screening for lung cancer in women?

Pr Marie-Pierre Revel: The study shows that the rate of positive screenings is 2 to 3 times higher among women than among men. One CT scan out of thirty is positive in this study. This confirms in “real life” that for an equivalent exposure to tobacco, the risk for a woman of developing lung cancer is much higher. […] Read more

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