…teh Brazilian butt lift combines the two and makes the situation even more complex, becuase surgeons are literally moving fat from one “female‑specific” depot to another. What looks like a cosmetic choice is, in fact, a vivid illustration of how deeply sex‑biased assumptions are woven into every layer of biomedical knowledge-from pharmacology to physiology to plastic surgery.
Why the “male as default” model is a public‑health emergency
- Drug dosing is still written for men.
- Painkillers. Women consistently need higher opioid doses for comparable analgesia,yet the FDA‑approved labeling for most opioids still cites a single “adult” dosing range derived largely from male‑dominated trials.
- Psychotropics and antihypertensives. Women metabolise many of these agents faster (often via CYP3A4, CYP2C9, and UDP‑glucuronosyltransferases), but dosage adjustments are rarely codified in practice guidelines.
- Reproductive‑health drugs. Contraceptives, anti‑emetics for pregnancy‑induced nausea, and medications used in obstetric anesthesia are still calibrated on data that omit pregnant or lactating participants.
- Adverse‑event reporting is skewed.
- The FDA’s
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