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  • Most effective drugs for obesity and its complications are semaglutide, tirzepatide, new European guideline says
  • Certain GLP-1 drugs are best for specific complications
  • The non-binding guideline emphasizes economic considerations in obesity treatment
Oct 2 (Reuters) – Novo Nordisk’s (NOVOb.CO)opens new tab and Eli Lilly’s (LLY.N)opens new tab blockbuster weight-loss drugs should be the first medicines doctors reach for to treat obesity and its complications, a major European medical association advised on Thursday.

Semaglutide, the active ingredient in Novo’s Wegovy and Ozempic, and tirzepatide, sold as Zepbound and Mounjaro by Lilly, are so effective that they should be the first choice in almost all cases when substantial weight loss is necessary, according to a new guideline from the European Association for the Study of Obesity published in Nature Medicine.

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When a lesser degree of weight loss is required, other medications can be considered, including liraglutide, an older, less effective drug from the same class, naltrexone–bupropion, and phentermine-topiramate, the guideline says.

Novo shares were up 2.2% at 1007 GMT, outperforming European pharmaceuticals peers.

The EASO guidelines are non-binding on individual countries.

Semaglutide, tirzepatide, and other drugs from the class known as GLP-1 agonists are completely transforming care of obesity and its complications, coauthor Dr. Andreea Ciudin of Vall d’Hebron University Hospital in Barcelona said in a statement.

Although no treatment algorithm can replace the nuanced clinical judgment necessary for comprehensive patient care, the new guidelines can serve to support therapeutic decision-making in obesity, she said.

SPECIFIC DRUGS FOR SPECIFIC CONDITIONS

The guideline authors analyzed previous clinical trial results, evaluating the impact of medications on weight loss, their safety profile, and their effectiveness in the presence of specific complications.

For patients with the physical consequences of too much fatty, or adipose, tissue, tirzepatide should be considered as the first-line treatment for addressing obstructive sleep apnea, and semaglutide for those with knee osteoarthritis, the authors determined.

For patients with conditions linked with obesity-related metabolic and immune dysfunction, they recommend semaglutide as a first choice for those with a history of heart disease or stroke, tirzepatide for individuals with non-alcoholic fatty liver disease, and either tirzepatide or semaglutide for those with prediabetes or type 2 diabetes.

The class of drugs was originally developed to treat type 2 diabetes.

While the drugs are expensive and economic considerations are complex, the cost of not treating obesity at early stages, “thus enabling the progression to complications and end-organ damage, should be weighed equally in health policy and clinical decision-making,” the guideline authors wrote.

The management of obesity should not be limited to weight loss and its complications but should focus on enhanced mental well-being, physical fitness, social functioning, and overall health and quality of life as well, they also said.

Most of the newer medications have not been evaluated for the treatment of individual complications, they acknowledge.

Still, the authors say, the weight-loss effects have been strongly associated with improvements in various complications and there is growing potential for them to positively influence a broader range of disorders such as chronic kidney disease, neurodegenerative diseases, polycystic ovary syndrome, certain cancers, and mental health conditions.

“Given the rapid advances in the field of medications to treat obesity, EASO intends to update the present treatment algorithm regularly to incorporate the latest available evidence,” society President Professor Volkan Yumuk of Istanbul University-Cerrahpaşa said in a statement.

The American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society jointly advised in June that GLP-1 treatment must be accompanied by nutritional and lifestyle strategies.

“Although GLP‐1s alone can produce significant weight reduction and related health benefits, several challenges limit its long‐term success for individuals and populations,” including gastrointestinal side effects, risk of nutrient inadequacies, muscle and bone loss, high costs, frequent discontinuation, and weight regain,” the advisory said.

Reporting by Nancy Lapid; Editing by Caroline Humer, Bill Berkrot and Louise Heavens

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What are the key mechanisms through which Wegovy (semaglutide) and Mounjaro/Zepbound (tirzepatide) contribute to weight loss?

European Doctors advocate Novo Nordisk and Eli Lilly Weight-Loss Drugs as Primary Obesity Treatment Options

The Shifting Paradigm in Obesity Management

European medical professionals are increasingly endorsing medications like Novo Nordisk’s Wegovy (semaglutide) and Eli Lilly’s Mounjaro (tirzepatide) – and now Zepbound (tirzepatide) – not merely as adjuncts to lifestyle interventions, but as primary treatment options for obesity. This represents a significant shift in how obesity, a chronic disease, is approached. For years, the focus remained heavily on diet and exercise, often with limited long-term success. Now, a growing body of clinical evidence supports the efficacy of these GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists in achieving significant and sustained weight loss.

This change isn’t about dismissing the importance of healthy habits; it’s about recognizing that obesity is a complex physiological condition often requiring pharmacological intervention. The conversation around weight management is evolving.

Understanding the Medications: Wegovy, Mounjaro & Zepbound

These drugs mimic naturally occurring hormones in the body, influencing appetite and food intake. Here’s a breakdown:

* Wegovy (Semaglutide): A GLP-1 receptor agonist originally approved for type 2 diabetes, Wegovy is now specifically indicated for chronic weight management.It works by slowing gastric emptying, increasing feelings of fullness, and reducing appetite. Clinical trials have demonstrated an average weight loss of around 15% in patients using Wegovy alongside lifestyle changes.

* Mounjaro/Zepbound (tirzepatide): A dual GIP and GLP-1 receptor agonist,tirzepatide has shown even more impressive results in clinical trials. Zepbound, the higher-dose version specifically for obesity, has demonstrated average weight loss exceeding 20% in clinical studies. It impacts both appetite and glucose regulation.

* Mechanism of Action: Both classes of drugs work on the brain’s appetite centers, reducing cravings and promoting satiety. They also improve insulin sensitivity, which is particularly beneficial for individuals with obesity and related metabolic disorders.

Why the Change in Approach? Evidence & Clinical Data

The advocacy from European doctors isn’t based on hype; it’s rooted in robust clinical data. Several factors contribute to this shift:

  1. High Obesity Rates: Europe, like much of the world, is facing an obesity epidemic. Customary methods haven’t adequately addressed the scale of the problem.
  2. Chronic Disease Recognition: Obesity is now widely recognized as a chronic, relapsing disease, not simply a matter of willpower. This understanding necessitates a more thorough and frequently enough pharmacological approach.
  3. Clinical Trial Results: Landmark trials, such as the SELECT trial with semaglutide demonstrating cardiovascular benefits in overweight/obese individuals without diabetes, have bolstered confidence in these medications.
  4. comorbidity reduction: these drugs have been shown to improve or resolve obesity-related comorbidities like type 2 diabetes, hypertension, sleep apnea, and non-alcoholic fatty liver disease (NAFLD). This holistic benefit is a key driver of physician support.

Benefits Beyond Weight Loss: A holistic Impact

The advantages of utilizing these medications extend far beyond the numbers on the scale.

* Improved Cardiovascular Health: Reduced risk of heart attack, stroke, and other cardiovascular events.

* Diabetes Management: Enhanced glycemic control and potential for diabetes remission.

* Reduced Joint Pain: Weight loss alleviates stress on joints, improving mobility and reducing pain.

* Enhanced Quality of Life: Improved physical function, mental well-being, and overall quality of life.

* Metabolic Syndrome Resolution: Advancement in multiple metabolic risk factors associated with metabolic syndrome.

Practical Considerations for Patients & Physicians

While these medications offer significant promise, they aren’t without considerations:

* Side Effects: Common side effects include nausea, vomiting, diarrhea, and constipation. These are typically mild to moderate and often subside with continued use.

* Cost & Access: The cost of these medications can be substantial, and access may be limited depending on healthcare systems and insurance coverage.

* Lifestyle Integration: These drugs are most effective when combined with lifestyle modifications,including a healthy diet and regular physical activity. They are not a “magic bullet.”

* Long-Term Use: Obesity is a chronic condition, and long-term medication use may be necessary to maintain weight loss.

* Monitoring: Regular monitoring by a healthcare professional is crucial to assess efficacy, manage side effects, and ensure overall health.

real-World Examples & emerging Trends

Several European countries are actively integrating these medications into their national obesity treatment guidelines. For exmaple, the UK’s National Health Service (NHS) has begun offering Wegovy to eligible patients through a structured weight management program. Denmark has also seen widespread adoption.

Furthermore,research is ongoing to explore the potential of combination therapies and personalized treatment approaches based on individual patient characteristics.The future of obesity treatment is highly likely to involve a more tailored and multifaceted approach,with medications playing a central role.

Addressing Concerns & Misconceptions

There’s been some public debate surrounding the use of these drugs, with concerns about potential rebound weight gain after discontinuation. While this is a valid concern, studies suggest that maintaining lifestyle changes after stopping medication can mitigate this risk. It’s crucial to have open and honest conversations with patients about

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8.fa449.text.we have seen it through.com base

What specific aspects of Meta‘s default timeline settings where found to be in violation of GDPR?

Dutch Court Mandates Meta to modify Default Timeline Settings on Facebook and Instagram

The Ruling: A Win for User Privacy

On October 2nd, 2025, a Dutch court delivered a significant blow to Meta’s data collection practices, ordering the tech giant to modify the default timeline settings on both Facebook and Instagram. This landmark decision stems from a case brought forth by privacy advocates concerned about the extensive tracking of user activity, even for individuals not actively using the platforms. The core of the issue revolves around Meta’s default settings which automatically collect data on user behavior, contributing to targeted advertising and personalized content recommendations.

The court ruled that Meta’s previous settings violated the General Data Protection Regulation (GDPR), specifically regarding the requirement for explicit consent for data processing. The judgment mandates that Meta must provide users with a clear and easily accessible option to opt-out of this data collection, making the privacy-respecting choice the default setting. This impacts millions of users across the Netherlands and sets a potential precedent for similar rulings in other European Union member states.

Understanding the Changes to Facebook & Instagram Timelines

The specific changes required by the Dutch court center around how meta utilizes data from users’ timelines – the chronological feed of posts,stories,and interactions. Previously,even users who didn’t actively engage with posts (like,comment,share) had their scrolling behavior tracked. This data was used to build detailed profiles for ad targeting.

Here’s a breakdown of the key modifications Meta is now legally obligated to implement:

* Default Privacy: The default setting must now prioritize user privacy, limiting data collection on timeline scrolling.

* Explicit opt-In: Users must actively choose to allow Meta to track their timeline activity for personalized advertising. A clear and concise explanation of what data is collected and how it’s used is required.

* Simplified Controls: The opt-out process must be straightforward and easily accessible within the Facebook and Instagram settings. Buried or complex settings are no longer acceptable.

* Transparency Reports: Meta is expected to publish regular transparency reports detailing the number of users who have opted-out of data collection.

Impact on Meta’s Advertising Revenue & Business Model

Meta’s business model heavily relies on targeted advertising,fueled by the vast amount of data collected from its users. This court ruling directly challenges that model. While the immediate financial impact is challenging to quantify, analysts predict a potential decrease in ad revenue, particularly within the European market.

Here’s how the changes coudl affect Meta:

  1. Reduced Ad Targeting Accuracy: Fewer data points mean less precise ad targeting, potentially lowering the effectiveness of advertising campaigns.
  2. Increased Cost Per Acquisition (CPA): Advertisers may need to spend more to reach the same number of potential customers.
  3. Shift Towards contextual Advertising: Meta may need to invest more in contextual advertising – displaying ads based on the content being viewed rather than user profiles.
  4. Pressure for Similar Regulations: This Dutch ruling could inspire similar legal challenges in other countries, further restricting Meta’s data collection practices globally.

What This Means for Facebook & Instagram Users

For the average Facebook and Instagram user, this ruling translates to greater control over their personal data and increased privacy. Users will now have a more meaningful choice about whether or not their activity on the platforms is tracked for advertising purposes.

Here’s what users can expect:

* Prompted Choices: Expect to see prompts within Facebook and Instagram asking you to explicitly consent to data collection.

* Easier Privacy Settings: Navigating privacy settings should become more intuitive and user-friendly.

* Reduced Personalized ads: If you opt-out of data collection, you may see fewer ads tailored to your specific interests.

* Increased Awareness: The ruling raises awareness about data privacy and empowers users to make informed decisions about their online activity.

Meta’s Response and Potential Appeals

Meta has publicly stated it is indeed reviewing the court’s decision and evaluating its options, including a potential appeal. The company maintains that it complies with GDPR regulations and that its data collection practices are necessary to provide personalized experiences and support its advertising ecosystem.

As of October 2nd,2025,Meta has not announced a specific timeline for implementing the required changes. However, given the legal weight of the ruling, compliance is inevitable.The company may attempt to mitigate the impact by focusing on alternative data collection methods or by developing new advertising technologies that rely less on individual user tracking.

The Broader Implications for Data Privacy & Tech Regulation

This case is a significant victory for digital privacy advocates and underscores the growing scrutiny of Big Tech’s data practices. It demonstrates that courts are willing to enforce GDPR regulations and hold companies accountable for violating user privacy.

This ruling could have far-reaching consequences:

* Strengthened GDPR Enforcement: It signals a more aggressive approach to GDPR enforcement across the EU.

* Increased Regulatory Pressure: Other tech companies may face similar legal challenges if their data practices are deemed to be in violation of privacy

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Suffrage Party Courts Foreign Influence, Sparks Debate on Japan’s Political Landscape

Tokyo, Japan – The suffrage party, which gained traction in July’s house of Councillors election with its “Japanese first” platform, is actively forging relationships with figures like former US presidential aide Steve Bannon adn right-wing political parties in Europe. This move aims to amplify the party’s influence both domestically and internationally by aligning with a global network of conservative “anti-globalism” advocates.

Party representative Kamiya Sohoke and four other officials feature in US disclosure documents outlining these efforts to court international allies. The party seeks to break what it perceives as stagnation in Japanese politics and increase its international profile.

“We are not in an era were we are going to do something about Japan alone,” Kamiya said in an interview with Reuters. The party is actively seeking recognition from influencers, politicians, and media both domestically and abroad.

To facilitate these efforts, the Suffrage Party established an international foreign relations department in September, led by Yamanaka Izumi, a newly elected member of the House of Councillors. Yamanaka, a graduate of a US university, believes increased international recognition will help shield the party from the criticism faced by those who challenge the status quo in Japan – a cultural tendency to pressure those who “stand out.”

The party has already hosted prominent figures associated with the American right, including Charlie Kirk, a conservative political activist, as part of such outreach. Following Kirk’s death shortly after the event, Yamanaka attended his memorial service in Arizona.

Further demonstrating this outreach, Kamiya has sought appearances on podcasts hosted by Steve Bannon and Tucker Carlson, both prominent figures in the American conservative media landscape. A document filed under the Foreign Agent Registration Act indicates that Matthew Brainard, a former Trump campaign staffer, assisted in initiating contact, stating his support for the party is voluntary and unpaid.

Bannon has expressed interest in having Kamiya appear on his program, describing him as a “revolutionary force” in Japanese politics. Carlson has also voiced support for the Suffrage Party’s efforts to curb immigration, which it frames as a vital protection of Japanese culture.

The suffrage Party also engaged with co-leaders of the German far-right party AfD in August, receiving supportive messages regarding its policies.

Political analysts suggest this move could bolster the party’s sustainability. Jeffrey Hall, a lecturer at Kanda University of Studies, stated, “What the suffrage Party talks about…meeting with people who say similar things…that’s going to give them staying power and force people to take them seriously.”

While Japan’s foreign-born population currently stands at around 3.8%, a record high, it remains substantially lower than that of the US and many European nations, a factor the party leverages in its messaging. This push for international validation signals a significant shift in Japanese politics, as the Suffrage Party attempts to transcend domestic boundaries in its pursuit of influence.

How might this alliance impact Japan’s relationships with China and South Korea, considering their existing geopolitical tensions?

Japan’s Suffrage Party Collaborates with Western Right-Wingers to Boost Global Recognition

The Unlikely Alliance: A Deep Dive

Recent months have seen a surprising, and strategically calculated, partnership emerge between the Japan Innovation party (日本維新の会 – Nihon Ishin no Kai), often referred to as the Japan Suffrage Party, and several prominent figures and organizations on the Western political right. This collaboration isn’t about ideological alignment in the traditional sense, but a pragmatic effort to elevate Japan’s international profile and influence, particularly concerning constitutional reform and national security. The core strategy revolves around leveraging established networks and amplifying messaging through sympathetic media outlets.

Historical Context: Japan’s Political Landscape & Constitutional Revision

Understanding this alliance requires a grasp of Japan’s post-war political trajectory. The current constitution, drafted under US occupation, contains Article 9, which renounces war. The Japan Innovation Party has long advocated for revising this article, aiming to grant Japan a more robust self-defense force and a greater role in international security. This position,while gaining traction domestically,has faced resistance from pacifist elements and concerns about regional stability. Constitutional reform in Japan is a complex issue, deeply rooted in historical trauma and national identity.

Identifying the Western Partners: Key Players & Their Motivations

The Western connections aren’t monolithic. They span a spectrum of conservative and nationalist groups,primarily in the United States and Europe. Key players include:

* Think Tanks: Several US-based think tanks known for advocating hawkish foreign policy positions have begun publishing articles and hosting events featuring Japan innovation Party representatives. These organizations provide a platform for disseminating pro-revisionist arguments to policymakers and the public.

* Political Commentators: Right-leaning political commentators and media personalities have increasingly highlighted japan’s security concerns and the need for a stronger Japanese military, often framing it as a counterweight to China’s growing influence.

* European nationalist Groups: Connections,tho less publicized,exist with certain European nationalist movements who share a common ground in advocating for national sovereignty and a rejection of perceived globalist agendas. This is often framed around shared cultural values and a resistance to perceived external pressures.

* Lobbying Firms: Discreet lobbying efforts in Washington D.C. and Brussels, funded by Japanese interests, are working to shape perceptions and build support for Japan’s policy goals. Japan lobbying efforts are increasing in Western capitals.

The motivations of these Western partners are varied. Some genuinely believe in a stronger US-Japan alliance as a bulwark against China. Others see Japan as a valuable economic and strategic partner. Still others are drawn to the nationalist rhetoric and the potential for forging alliances with like-minded groups.

the Mechanics of Collaboration: How the Partnership Works

The collaboration takes several forms:

  1. Joint Conferences & Seminars: Co-hosted events provide a platform for exchanging ideas and building relationships. These events frequently enough focus on themes like regional security,economic cooperation,and the future of the US-Japan alliance.
  2. Media Outreach: The Japan Innovation Party leverages Western media contacts to amplify its message.This includes op-eds, interviews, and appearances on talk shows.
  3. Social Media Campaigns: Coordinated social media campaigns target specific audiences with tailored messaging. Digital diplomacy Japan is becoming more refined.
  4. Research & Policy Papers: Jointly commissioned research papers provide intellectual ammunition for advocating policy changes.
  5. Parliamentary Exchanges: Visits and meetings between Japanese and Western parliamentarians facilitate dialog and build personal connections.

Benefits for the Japan Innovation Party: Increased Global Visibility

the primary benefit for the Japan Innovation Party is increased global visibility and legitimacy.By aligning with established Western figures and organizations, the party gains access to a wider audience and a more credible platform for promoting its agenda. This is particularly vital in the context of Japan’s international relations,which have historically been constrained by its pacifist constitution.

Potential Risks & Criticisms: navigating a Delicate balance

this alliance isn’t without risks. Critics argue that associating with far-right groups could damage Japan’s reputation and alienate potential allies. Concerns have been raised about the potential for the Japan Innovation Party to be seen as embracing extremist ideologies. Furthermore, the collaboration could exacerbate tensions with neighboring countries, particularly China and South Korea, who view japan’s growing military ambitions with suspicion. Geopolitical risks Japan faces are amplified by this strategy.

Case Study: The 2024 Tokyo Security Dialogue

The 2024 Tokyo Security Dialogue, a high-profile conference on regional security, provides a concrete example of this collaboration in action. The event featured prominent speakers from both Japan and the United States, including several individuals with strong ties to conservative think tanks. the dialogue focused heavily on the need for a stronger US-Japan alliance to counter China’s growing influence, and the importance of revising Article 9 of the Japanese constitution. The event received meaningful media coverage in both Japan and the United States, effectively amplifying the Japan Innovation Party’s message.

Practical Implications for Investors & businesses

For investors and businesses operating in

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