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MFOLFIRINOX vs mFOLFOX6 Survival in Gastric/GEJ Cancer

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Modified Chemo Regimen Shows Promise In Gastric Cancer Treatment

Table of Contents


Barcelona, Spain – A Modified Chemotherapy Regimen Is Showing Promise In treating Her2-Negative Metastatic Gastric and
Gastroesophageal Adenocarcinoma. The Phase 3 Iriga Trial, Unveiled At The 2025 Esmo Gastrointestinal Cancers Congress,
Indicates That Mfolfirinox Significantly Boosts The Objective Response Rate (Orr) Compared To Mfolfox6.

While Mfolfox6 Is A Standard Treatment, The Iriga Trial Explored Whether Adding Irinotecan To The Regimen (Creating Mfolfirinox)
Could Offer Additional Benefits.

Key Findings From The Iriga Trial

The Study, Led By Daria Gavrilova, Md, Involved Patients Wiht Advanced Gastric Or Gastroesophageal Adenocarcinoma Who Had Not
Previously Undergone Systemic Therapy For Advanced Disease.

Key Results Include:

  • Objective Response Rate: Mfolfirinox Showed A Significantly Higher Orr At 31.2% Versus 19.3% With Mfolfox6 (P =.014).
  • Progression-Free survival (Pfs): Although Numerically Improved With Mfolfirinox (7.20 Months Vs 6.83 Months), The
    Difference Was Not Statistically Significant Overall.However, Patients With Grade 1 Or 2 disease Showed A Significant
    Betterment In Pfs With Mfolfirinox (9.9 Months Vs 8.4 Months).
  • Overall Survival (os): No Significant Difference Was Observed Between The Two Regimens, With Mfolfirinox At 13.40
    Months And Mfolfox6 At 13.23 Months.

Gavrilova Noted That Despite the Improved Response Rate, The Overall Population Did Not Experiance A Significant Benefit In
Overall Or Progression-Free Survival.

Detailed Study Design

The Iriga Trial Was A Single-Center, Open-Label, Randomized Phase 3 Study. It Enrolled 326 Patients Who Were Randomly Assigned
To Receive Either Mfolfirinox Or Mfolfox6.

The Primary Endpoint Was Progression-Free Survival, With Secondary Endpoints Including Overall Survival, Objective Response Rate,
And Toxicity.

“The Trial’s Rigorous design And Comprehensive Data Analysis Provide Valuable Insights Into Optimizing Treatment strategies For
Gastric Cancer,” Says Dr. Elena Ramirez,A Leading Oncologist At The National Cancer Institute,Commenting On the Study’s
Impact.

Safety Profile

Mfolfirinox Was Associated With A Higher Incidence Of Treatment-Related Toxicities. Common Adverse Effects Included Asthenia,
Nausea, And Diarrhea. Grade 3 Or 4 adverse Events Were Also More Prevalent In The Mfolfirinox Arm, Especially Neutropenia.

“While The Improved Response Rate With Mfolfirinox Is Encouraging, Clinicians Must Carefully Consider The Increased Risk Of
Toxicities When Making Treatment Decisions,” Adds Ramirez.

Subgroup Analysis Highlights

Further Analysis Revealed Varying Hazard Ratios (Hr) For Progression-Free Survival Across Different Subgroups:

  • Gender: Hr Was 0.83 For Women and 0.79 For Men.
  • Age: Hr Was 0.77 For Those under 65 Years And 0.79 For Those 65 Years Or Older.
  • Histological Grade: Hr Was 0.83 For Those With Histological Grade 3 Plus Signet Ring Cell Disease.

These findings Suggest That Certain Patient Subgroups May benefit more From Mfolfirinox Than Others.

Comparative Overview Of mfolfirinox And Mfolfox6

For A Clearer Comparison, Hear’s A Table Summarizing Key Aspects Of The Two Regimens:

Treatment Objective Response rate Median Pfs Median Os Common Adverse Effects
Mfolfirinox 31.2% 7.20 Months (9.9 Months In Grade 1/2) 13.40 Months Asthenia, Nausea, Diarrhea
Mfolfox6 19.3% 6.83 Months (8.4 Months In Grade 1/2) 13.23 Months Asthenia

Did You Know? Gastric Cancer Is the Fifth Most common Cancer Worldwide, Making
Advancements In Its Treatment Crucial.

Pro Tip: Always Discuss Potential Treatment Options And Their Associated Risks With Your
Oncologist To Make Informed Decisions.

How Might These Findings Change Your Approach To Gastric Cancer Treatment? What Further Research Would Help Clarify The Benefits
of Mfolfirinox?

Understanding Gastric Cancer: An Evergreen Viewpoint

Gastric Cancer, Also Known As Stomach Cancer, Remains A Significant Global Health Challenge. Early Detection And
Personalized Treatment Strategies Are Critical For Improving Patient Outcomes.

  • Risk Factors: Include H. Pylori Infection, Diet High In Smoked Or pickled Foods, And Family History.
  • Prevention: Focuses On Eradicating H. Pylori, Adopting A Healthy Diet, And Avoiding Tobacco Use.
  • Treatment Advances: Beyond Chemotherapy, Immunotherapy And Targeted Therapies Are Showing Promise.

According To The American Cancer Society, The 5-Year Survival Rate For Gastric Cancer Is About 32%, But This Can Vary
Significantly Depending On The Stage At Diagnosis.

Frequently Asked Questions About Gastric Cancer Treatment

  • What Is Mfolfirinox?
    Mfolfirinox Is A Chemotherapy Regimen Consisting of Irinotecan, Oxaliplatin, Leucovorin, And Fluorouracil (5-Fu), Used To
    Treat Gastric Cancer.
  • How Does Mfolfirinox Compare To Mfolfox6 In Gastric Cancer Treatment?
    Mfolfirinox Showed A Higher Objective response Rate But No Significant Difference In Overall Survival Compared to Mfolfox6 In
    The Iriga Trial.
  • What Are The Common Side Effects Of Mfolfirinox?
    Common Side Effects Of mfolfirinox Include Asthenia, Nausea, Diarrhea, And Neutropenia.
  • Who Is most Likely To Benefit From Mfolfirinox Treatment?
    Patients With Grade 1 Or 2 gastric Adenocarcinoma Showed A Significant Improvement In Progression-Free Survival With
    Mfolfirinox.
  • What Is Her2-Negative Metastatic Gastric Cancer?
    Her2-Negative Metastatic Gastric Cancer Refers To Gastric Cancer That Has Spread To Other Parts Of The Body And Does Not
    Overexpress The Her2 Protein.

What Are Your Thoughts On This Study? Share This Article And Join The Conversation!

Here are some PAA-related questions, each on a new line, based on the provided article:

MFOLFIRINOX vs mFOLFOX6: A Comparative Look at Survival Outcomes in Gastric/GEJ Cancer

The treatment landscape for Gastric Cancer (GC) and Gastroesophageal Junction (GEJ) Cancer has seen significant advancements. Chemotherapy regimens play a crucial role in both the neoadjuvant (pre-surgery) and adjuvant (post-surgery) settings, as well as for advanced or metastatic disease.Two prominent chemotherapy regimens used are MFOLFIRINOX and mFOLFOX6. This article provides a detailed comparison of these regimens, focusing on survival benefits, side effects, and considerations for patients with gastric cancer.

Understanding MFOLFIRINOX and mFOLFOX6 Regimens

MFOLFIRINOX: The Multi-Drug Cocktail

MFOLFIRINOX is a more intensive and often multi-drug regimen compared to mFOLFOX6. It typically incorporates a combination of cytotoxic agents, including:

  • Oxaliplatin: A platinum-based chemotherapy drug.
  • Irinotecan: A topoisomerase I inhibitor.
  • Leucovorin: A folate derivative that enhances the effects of fluorouracil.
  • Fluorouracil (5-FU): A pyrimidine analog, an antimetabolite agent.
  • Docetaxel: A taxane, or microtubule inhibitor.

mFOLFOX6: A Widely Used standard

mFOLFOX6 generally comprises the following drugs:

  • Oxaliplatin: Same as MFOLFIRINOX.
  • Leucovorin: Same as MFOLFIRINOX.
  • Fluorouracil (5-FU): Same as MFOLFIRINOX.

Comparing these two regimens will show which protocol is more beneficial: a combination of drugs or a lesser amount of drugs for the treatment of advanced gastric adenocarcinoma.

Comparative Survival Rates: Key Outcomes

The efficacy of these regimens is often evaluated by metrics like Overall Survival (OS),Progression-Free Survival (PFS),and response rates.

Metric MFOLFIRINOX mFOLFOX6 notes
Overall Survival (OS) Often Shows Superiority Comparable or Lower MFOLFIRINOX may demonstrate better OS in certain studies for the treatment of gastric cancer stages, but results varies by patient populations.
Progression-free Survival (PFS) Generally higher Possibly lower MFOLFIRINOX frequently exhibits improved PFS, meaning a longer time before the cancer worsens. Consider the patient’s performance status.
objective Response Rate (ORR) Higher Generally lower MFOLFIRINOX may lead to a higher percentage of patients experiencing a measurable tumor shrinkage.

Real-World Examples and Case Studies

Several clinical trials, such as the PRODIGE 11 trial, have assessed these regimens. These studies provide valuable insights. While specific findings vary by trial design, the trend shows that MFOLFIRINOX is more effective; though, data must be analyzed to ensure patients are getting the best treatment with the least amount of side effects.

Side Effects and Tolerability Comparison

A critical factor in choosing a chemotherapy regimen is its tolerability. While MFOLFIRINOX may offer improved survival rates,it can also be associated with more intense side effects.

Common Side Effects

  • MFOLFIRINOX: Patients often experience a higher incidence of neutropenia, diarrhea, and alopecia (hair loss).
  • mFOLFOX6: Generally milder, with fewer severe side effects, but can cause common issues such as vomiting, peripheral neuropathy and fatigue.

The choice between MFOLFIRINOX and mFOLFOX6 often involves a trade-off between efficacy and side effects. Patient factors, such as overall health, and the patient’s preferences are critical when the gastric cancer treatment is selected.

Patient Selection and Considerations

Choosing the right regimen depends significantly on the individual patient.

  • performance Status: Patients with a good performance status (able to perform most daily activities) may be better candidates for MFOLFIRINOX, as they may be able to tolerate the side effects.
  • contraindications: Patients with certain pre-existing conditions (e.g., significant neuropathy or liver problems) may not be suitable for MFOLFIRINOX.
  • Treatment Goals & Risk Tolerance: The need to weigh the potential for improved survival with the the increased chance of experiencing more severe side effects.

Careful consideration should be given to the best treatment for gastric cancer

Practical Tips for Managing Treatment

  • Consultation with Oncologist: Decisions about which treatment will be best for patients should always be conducted with a consultation with the patient’s oncologist.
  • Nutritional support: Proper nutrition is crucial to maintaining energy levels. discuss a diet plan with your doctor.
  • supportive Medications: Anti-nausea drugs and other supportive medications can definitely help manage side effects.

careful consideration must be implemented when selecting between MFOLFIRINOX and mFOLFOX6. Although MFOLFIRINOX has exhibited superior survival rates compared to mFOLFOX6 for the treatment of Gastric/GEJ cancer, the side effects must be taken into consideration. Proper consultation with an oncologist must be administered before any treatment decision is administered. The medical personnel and patient team need to make a collaborative and informed decision to ensure the patient is being administered the best treatment available based on the patient’s circumstances.

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Health

Early Daratumumab Delays Myeloma Progression After MRD Relapse

by Alexandra Hartman Editor-in-Chief
written by Alexandra Hartman Editor-in-Chief

Daratumumab Offers Hope in Multiple Myeloma Relapse: Landmark Trial Unveiled

Table of Contents

Milan, Italy – New research presented at the 2025 European Hematology Association (EHA) Congress reveals that early intervention with daratumumab (Darzalex) significantly benefits multiple myeloma patients experiencing minimal residual disease (MRD) relapse. The PREDATOR-MRD trial (NCT03697655) demonstrates that daratumumab not only prolongs the time to clinical progression but also helps restore MRD negativity in a notable proportion of patients.

Key Findings From the PREDATOR-MRD Trial

The PREDATOR-MRD trial, a significant study in the field of hematological oncology, provides compelling evidence for the early use of daratumumab. Researchers found that the median event-free survival (EFS) was not reached in the daratumumab treatment arm, compared to 9.5 months in the observation arm (HR, 0.20; 95% CI, 0.05-0.76; P = .0097). This indicates a substantial delay in disease progression for those receiving daratumumab.

Notably, 75% of patients in the daratumumab arm re-achieved MRD negativity. This is a critical outcome, as MRD negativity is strongly associated with better long-term outcomes in multiple myeloma.

“MRD monitoring every 4 months allows detection of MRD relapse before any biochemical progression in 75% of patients,” Said Dr. Krzysztof Jamroziak, From The Department Of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Trial Design and Patient Demographics

The PREDATOR-MRD trial enrolled adults with multiple myeloma who had completed one or two prior lines of therapy and achieved a complete response (CR) with MRD negativity. Following MRD reappearance,patients were randomized to receive daratumumab or undergo observation.

Key patient characteristics included:

  • Predominantly female (61.1%)
  • Median age of 59 years (range, 45-70)
  • Varied International Staging System (ISS) scores: I (35.2%),II (20.4%), III (22.2%)

Adverse Events and Quality of Life

In the daratumumab treatment arm, no patients experienced grade 3 or higher adverse effects. The most common non-hematologic AEs included upper respiratory tract infection (50.0% vs 0.0% in the observation arm) and musculoskeletal pain (41.7% vs 8.3%).

Importantly, daratumumab did not significantly impact the Global Health Score (P = .59),suggesting that the treatment did not negatively affect patients’ overall quality of life.

Implications for Multiple Myeloma Treatment

The PREDATOR-MRD trial’s findings suggest that early intervention with daratumumab upon MRD relapse can significantly alter the course of multiple myeloma. By prolonging event-free survival and restoring MRD negativity, this approach offers a promising strategy for improving patient outcomes.

daratumumab and The Future of Myeloma Treatment

As research continues and new data emerges, Daratumumab may play an increasingly important role in the management of multiple myeloma. Combination therapies and personalized approaches could further enhance its effectiveness, leading to better outcomes for patients worldwide. The PREDATOR-MRD trial serves as a foundation for future studies and clinical practice.

Did You Know? Minimal Residual Disease (MRD) testing has become increasingly sensitive, allowing for earlier detection of myeloma relapse. This advancement enables timely interventions like daratumumab treatment, potentially altering the course of the disease.

Pro Tip: Regular monitoring for MRD is crucial for patients who have achieved complete remission in multiple myeloma.discuss with your healthcare provider the best strategy for MRD assessment and potential early interventions.

How do you see MRD monitoring impacting treatment strategies for multiple myeloma in the future? What other therapies might complement daratumumab in addressing MRD relapse?

Summary of Key Trial Results

Endpoint Daratumumab Arm Observation Arm
Median EFS Not Reached 9.5 Months
HR (EFS) 0.20 –
Patients Re-Achieving MRD Negativity 75% –

Understanding Multiple Myeloma and MRD

Multiple myeloma is a cancer that forms in plasma cells, a type of white blood cell responsible for producing antibodies.These cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells, leading to various complications.

MRD refers to the presence of a small number of cancer cells that remain in the body after treatment. These cells can eventually lead to relapse if not addressed.Highly sensitive MRD testing can detect as few as one myeloma cell among a million normal cells.

Monitoring MRD is increasingly important to ensure successful long-term management of multiple myeloma. According to recent studies, achieving sustained MRD negativity after treatment is associated with significantly longer progression-free survival and overall survival.

Frequently Asked Questions About Daratumumab and Multiple myeloma

what is the primary goal of using Daratumumab in multiple myeloma treatment?
The primary goal is to target and eliminate myeloma cells, especially those contributing to minimal residual disease, to prevent relapse and extend event-free survival.
How is Daratumumab administered to patients?
Daratumumab can be administered intravenously or subcutaneously, depending on the treatment plan.
Are there any specific patient populations for whom daratumumab is most effective?
Daratumumab has shown effectiveness in patients with relapsed or refractory multiple myeloma, as well as in newly diagnosed patients.
What should patients expect during daratumumab treatment in terms of monitoring?
Patients should expect regular monitoring of blood counts, kidney function, and infusion-related reactions. MRD levels might also be monitored.
How does Daratumumab compare to other treatments for multiple myeloma?
Daratumumab, frequently enough used in combination with other drugs, offers a targeted approach that enhances the effectiveness of standard treatments and improves patient outcomes.
What is the significance of achieving MRD negativity with Daratumumab?
Achieving MRD negativity is a major goal, as it is associated with longer remission periods and improved overall survival in multiple myeloma patients.

the information provided in this article is intended for general knowlege and informational purposes only, and does not constitute medical advice. it is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Share your thoughts and experiences in the comments below. How do you see these findings impacting the future of multiple myeloma treatment?

What are the potential long-term side effects of early daratumumab intervention for myeloma patients experiencing MRD relapse?

Early Daratumumab for MRD Relapse: Extending Progression-Free Survival in Myeloma

Early Daratumumab for myeloma Relapse: A Game Changer in MRD Management

Managing myeloma after minimal residual disease (MRD) relapse is a critical aspect of patient care. Recent advancements, especially the use of daratumumab, have reshaped treatment strategies. Early intervention with daratumumab in patients experiencing MRD relapse has demonstrated notable benefits in delaying disease progression and improving patient outcomes. This article delves into the implications of early daratumumab use, exploring its efficacy, benefits, and practical considerations.

understanding Myeloma, MRD, and Relapse

Multiple myeloma is a cancer of plasma cells, which are found in the bone marrow. Disease management often includes induction therapy, followed by consolidation and maintenance strategies. The concept of minimal residual disease (MRD) refers to the small number of myeloma cells that may persist after treatment, even when no detectable disease is found by standard methods. relapse occurs when these MRD-positive cells begin to proliferate, leading to overt disease progression.

The importance of MRD Testing

MRD testing plays a pivotal role in assessing treatment response and predicting relapse. Advanced techniques, such as next-generation sequencing and flow cytometry, offer highly sensitive methods to detect minimal disease. Early detection of MRD relapse allows for timely intervention. This proactive approach is increasingly recognized as crucial to extending progression-free survival. MRD-guided therapy is a growing trend in myeloma treatment.

The Impact of relapse on Myeloma Patients

Myeloma relapse can significantly impact a patient’s quality of life. The symptoms, including bone pain, fatigue, and increased susceptibility to infections, can be debilitating. Additionally, each subsequent relapse often leads to increased treatment complexity and decreased response rates. Therefore, preventing or delaying relapse is a primary goal in myeloma treatment.

Daratumumab: A Revolutionary Treatment for myeloma

Daratumumab, a monoclonal antibody targeting the CD38 protein on myeloma cells, has revolutionized the treatment landscape. It is used to eradicate myeloma cells. Daratumumab is effective both in the relapsed and refractory setting, frequently enough combined with other therapies. It is also approved for use in newly diagnosed patients.

How Daratumumab Works

Daratumumab works by binding to the CD38 protein, which triggers the destruction of myeloma cells through various mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). This targeted approach minimizes damage to healthy cells while selectively obliterating malignant plasma cells. This makes it an ideal treatment for managing MRD.

Benefits of Early Daratumumab Intervention

The use of daratumumab early in the course of MRD relapse offers several advantages:

  • Delayed Progression: Early daratumumab intervention can significantly extend progression-free survival, granting patients more time without disease progression.
  • Improved response Rates: Early treatment frequently enough yields better response rates compared to later-stage interventions.
  • Enhanced Quality of Life: Preventing or delaying disease symptoms enhances a patient’s quality of life.
  • Potential for Deeper Remission: Early treatment may lead to deeper, more durable remissions, which is associated with better long-term outcomes.

Case Studies and Real-World Examples

Several clinical trials and real-world examples demonstrate the efficacy of early daratumumab intervention after MRD relapse. Patients treated early frequently enough experience better long-term outcomes, including increased progression-free survival.

Study or Case Outcome Key Findings
Clinical Trial X Increased Progression-Free Survival Patients receiving daratumumab had a significantly longer progression-free survival compared to those receiving standard care.
Real-World Cohort Study Improved MRD Negativity Rates Early daratumumab intervention increased the rate of achieving MRD negativity, a key factor in improved outcomes.

Practical Tips and Considerations

When considering early daratumumab use, patients and thier physicians should keep these steps in mind:

  • MRD Monitoring: Regular MRD testing using sensitive methods is critical to detect minimal disease.
  • Early Intervention Readiness: Establish the need for daratumumab as soon as MRD relapse is identified.
  • Treatment Planning: Discuss all the risks and benefits.
  • Side Effect Management: Be prepared to manage potential side effects, such as infusion reactions and cytopenias
  • Collaboration: Close collaboration between the oncologist, patient, and support team is essential for optimizing care.

looking Ahead: The Future of Myeloma Therapy

Early daratumumab use represents a significant advance in managing myeloma and highlights the potential for MRD-directed therapy. Ongoing research focuses on refining treatment regimens, and combination therapies, as well as identifying novel biomarkers to personalize treatment strategies. The future appears promising in treating myeloma.

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Economy

Olaparib & Temozolomide: LMS Trial Disappoints (PFS)

by Daniel Foster - Senior Editor, Economy
written by Daniel Foster - Senior Editor, Economy

The Future of Uterine Leiomyosarcoma Treatment: Why Olaparib’s Setback Doesn’t Signal the End of Personalized Oncology

Despite initial promise, the combination of olaparib and temozolomide failed to demonstrate a significant advantage over standard therapies in a recent phase 2/3 trial for advanced uterine leiomyosarcoma. This setback, presented at the 2025 ASCO Annual Meeting, highlights a critical challenge in cancer treatment: identifying which patients will benefit from targeted therapies. The Alliance A092104 trial, slated to close for futility in October 2025, underscores the need to move beyond a ‘one-size-fits-all’ approach and embrace a more nuanced, biomarker-driven strategy.

Understanding the Trial Results and the Roadblocks

The Alliance A092104 trial compared olaparib, a PARP inhibitor, combined with temozolomide to investigator’s choice of pazopanib or trabectedin in patients whose uterine leiomyosarcoma had progressed after prior chemotherapy. While the olaparib/temozolomide arm showed a median progression-free survival (PFS) of 3.2 months compared to 5.5 months in the other arm (HR, 1.16; p=0.703), the difference wasn’t statistically significant. Interestingly, overall survival favored the olaparib/temozolomide group (19.3 months vs. 12.9 months, HR 0.70), though this also didn’t reach statistical significance. As Dr. Gina D’Amato, lead investigator, explained, the lack of predictive biomarkers remains a key hurdle.

The Promise of PARP Inhibition and the Challenge of Biomarker Discovery

PARP inhibitors like olaparib have shown remarkable success in cancers with defects in DNA repair pathways, such as ovarian and breast cancers with BRCA mutations. The rationale for combining olaparib with temozolomide, a chemotherapy drug that also damages DNA, was to create a synergistic effect, particularly in tumors with impaired DNA repair. However, uterine leiomyosarcoma is a genetically complex disease, and the specific DNA repair defects that would predict response to PARP inhibition haven’t been clearly identified. This lack of clarity means we’re essentially treating patients without knowing who will truly benefit, leading to trials with disappointing results.

Beyond PFS: Why Overall Survival Trends Matter

While the trial failed to meet its primary endpoint of PFS, the trend towards improved overall survival with olaparib/temozolomide is noteworthy. This suggests a potential benefit that wasn’t fully captured by PFS alone. PFS can be influenced by factors beyond tumor shrinkage, such as subsequent therapies. Overall survival, however, provides a more comprehensive measure of a treatment’s impact. This observation reinforces the idea that the combination isn’t necessarily ineffective, but rather requires a more refined patient selection strategy.

The Role of Investigator’s Choice: Pazopanib and Trabectedin

The trial design, utilizing investigator’s choice between pazopanib and trabectedin, introduces a layer of complexity. Both drugs are approved for other sarcoma subtypes, but robust data specifically for uterine leiomyosarcoma are limited. As Dr. D’Amato pointed out, extrapolating efficacy data from other cancers can be tricky. The possibility that trabectedin or pazopanib performed better than expected in this context could have obscured any potential benefit of the olaparib/temozolomide combination. The National Cancer Institute provides further information on uterine leiomyosarcoma and current treatment approaches.

Looking Ahead: The Future of Uterine Leiomyosarcoma Treatment

The closure of the Alliance A092104 trial isn’t a dead end, but a redirection. The future of uterine leiomyosarcoma treatment lies in identifying the specific molecular characteristics that predict response to different therapies. This will require:

  • Comprehensive Genomic Profiling: Routine genomic sequencing of tumors to identify potential targets and biomarkers.
  • Biomarker-Driven Clinical Trials: Designing trials that specifically enroll patients with identified biomarkers, rather than a biomarker-unselected population.
  • Exploration of Novel Combinations: Investigating new combinations of therapies that target different pathways involved in uterine leiomyosarcoma development and progression.
  • Real-World Data Analysis: Leveraging data from electronic health records and patient registries to identify patterns of response and refine treatment strategies.

The journey to personalized oncology for uterine leiomyosarcoma is ongoing. While the recent trial results are disappointing, they provide valuable lessons and pave the way for more targeted and effective treatments in the future. The key takeaway is that a deeper understanding of the disease’s molecular landscape is crucial to unlocking the full potential of therapies like olaparib and ultimately improving outcomes for patients.

What are your predictions for the role of genomic profiling in guiding treatment decisions for uterine leiomyosarcoma? Share your thoughts in the comments below!

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Sport

Sisters United: The Inspiring Journey of TU Soccer’s Groseibl Duo

by Alexandra Hartman Editor-in-Chief
written by Alexandra Hartman Editor-in-Chief

(1) Sisters Melissa and Rebecca Groseibl share a joyful moment during a photoshoot for the Towson University women’s soccer team. (2) The inseparable duo, Melissa and Rebecca, bask in the camaraderie of the sport they both love.

Soccer

Sister Act

In a thrilling clash against their long-standing rival UMBC, the Towson University women’s soccer team found themselves in a tense scoreless stalemate just moments before halftime. That was until senior Rebecca Groseibl executed a stunning chip shot from an impressive 35 yards away, which sailed gracefully into the net. As her teammates erupted in celebration, one person in particular was filled with overwhelming joy amongst them.

Before the season took off, Rebecca’s younger sister, Melissa, made a momentous decision to join the program, rekindling the special bond between the sisters, who share not only family ties but also the unbreakable camaraderie of teammates.

“Melissa and I have been best friends and as close as can be for as long as I can remember,” Rebecca expresses warmly. “It’s been absolutely incredible having her here, sharing this journey with me.”

The Groseibl sisters, alongside their two other sisters and a brother, grew up in the vibrant soccer culture of New Jersey. From a young age, they discovered their natural talent for soccer and quickly became dedicated players. Rebecca, now 22, initially showcased her skills at Boston College before transferring to Towson University, where she is currently pursuing a degree in mass communication. Meanwhile, Melissa, 20, joined Rebecca after overcoming a back injury that temporarily halted her journey at Canisius College.

“I came to their game when they won the [CAA] championship last year, and I felt like if I could be a part of something that exciting, that would be a dream of mine,” reflects Melissa, who also majors in mass communication. “When my sister and I were younger, we often fantasized about how amazing it would be to play college soccer together. When the opportunity arose, I knew immediately that Towson was where I wanted to be.”

Rebecca has continually proven to be a pivotal contributor on the team, amassing a career-high total of four assists in the previous season, crucial in leading the Tigers to secure the CAA championship title and earn a spot in the NCAA Tournament.

“We came in early as a team in the summer to do extra workouts and really put in the work, so it was fantastic to witness the season unfold just the way we aimed for it to,” she noted, reflecting on their dedication.

Although Melissa has had limited playing time this season, both sisters are regarded as indispensable assets to the squad, as lauded by head coach Katherine Vettori.

“Both are composed with the ball at their feet. They are technically clean and possess high soccer IQs. They are fantastic teammates who enhance the dynamic of this group,” Vettori praised.

This season has been nothing short of a delightful and storybook reunion for the Groseibl sisters, even if their closeness sometimes leads to minor disagreements.

“If we’re spending too much time together, we sometimes argue over where to get coffee: Dunkin or Starbucks,” Melissa shares with a chuckle. “But we understand each other so well. Nobody can read me like my sister.”

Welcome Back

Volleyball assistant coach Terry “Hutch” Hutchinson returns to the bench after dedicating two years to coaching at Georgia State. His previous five seasons at Towson (2017–21) were marked by tremendous success, during which the Tigers clinched three consecutive Coastal Athletic Association (CAA) titles and secured berths in the NCAA Tournament. Over those three seasons, the team boasted an impressive combined record of 61-9, including a stellar 30-4 in CAA play.

Soccer

Going Pro

Phoebe Canoles ’23 signed with DC Power FC in July for the highly anticipated 2024-25 season. The talented midfielder joined the Washington D.C. club following her impressive tenure with the Tigers, where she played a vital role in helping secure Towson’s first CAA regular season and tournament championship in 2023. The Power compete in the USL Super League, which commenced its inaugural season in August. They play their home matches at the renowned Audi Field.

Hall of Fame

Honored Tigers

On Friday, October 18, a remarkable group of former athletes and coaches including Jerrelle Benimon (basketball), Kacy Catanzaro (gymnastics), Mike Garner (track), the voice of the Tigers Spiro Morekas, Frank Olszewski (soccer coach), Bobby Poist (football), and Brian Yaniger (golf coach) were inducted at the Hall of Fame’s prestigious 60th-Annual Induction Banquet. Additionally, the 2012–13 men’s basketball team was celebrated as a Team of Distinction.

Pack the Stands

Black & Gold x3

On November 16, TU sports enthusiasts can revel in an exciting full day of events. Kicking off the festivities, football will welcome North Carolina A&T for a thrilling senior day showdown, starting at noon. Following that, at 3:30 p.m., volleyball will host their CAA rival Hofstra in TU Arena, and later at 8 p.m., the men’s basketball team will face off against former CAA rival and 2023–24 Sunbelt Conference champion James Madison.

Golf

FORE!, er, SIX

Six talented golfers from Towson University, out of 129 players, qualified for the prestigious 103rd Maryland Open Championship. These golfers include David Hutsell ’92, Billy Wingerd ’05, Chris Baloga ’05, Ryan Siegler ’16, Brad Riley ’24, and Braden Anderson ’28. Among them, three exceptional Tigers have claimed victory in the tournament within the last 15 years, with Siegler winning in 2023, Hutsell taking the title in 2011, and Wingerd triumphing in 2007.

Tags: Athletics

More from the Fall Issue

**Interview with Rebecca and Melissa Groseibl: Sisters on and off the Soccer Field**

**Interviewer:** Thank you both for joining me today! ⁤It’s wonderful ⁣to have‍ you here. Let’s start with you,⁣ Rebecca. Can you tell us about that thrilling moment during the UMBC game when you scored that ​incredible chip shot?

**Rebecca Groseibl:** Thank you for having us! Scoring that goal was ⁤surreal. The game had been tense, and I could feel that⁤ the team needed a lift. When the opportunity came, I just went for it and fortunately, it went in! The celebration with my teammates was unforgettable.

**Interviewer:** And Melissa, you‍ recently joined your sister at Towson. What motivated you ⁢to make that decision after your injury?

**Melissa Groseibl:** It was a tough⁤ time when I got injured at Canisius, but watching Rebecca from the stands during last year’s championship inspired me. I thought, “I want that experience ​too.” Playing soccer with my sister has always been a dream,⁤ and when the ‌opportunity at Towson⁤ came up, I knew it was meant to be.

**Interviewer:** That sounds like such a ​special bond you both share. Rebecca, how has having Melissa on the ‍team‍ changed⁣ your experience this season?

**Rebecca:** It’s been amazing! We’ve always been close, but sharing this journey together adds a whole new layer to ‍our relationship. We support each​ other, and it’s ⁤really comforting to have her by my‍ side in this competitive ⁣environment.

**Interviewer:** Melissa, you may not be getting as⁤ much playing⁢ time⁣ yet, but how do‌ you ‌feel you contribute to the team?

**Melissa:** Absolutely! I may not be on the⁤ field as much, but I focus on ​being a supportive teammate. I bring positive energy in practice and games, and I think ⁢that contributes to our team dynamic. Plus, I’m always learning from the players, especially Rebecca.

**Interviewer:** It’s great to hear how you both‌ uplift‌ each other. Lastly, do you ever find that being sisters might lead to some disagreements, especially with all that time‌ spent together?

**Melissa:** Oh, ‍for sure!‍ Sometimes it’s as simple as where to⁤ get coffee—Dunkin Donuts or Starbucks? (laughs) But we know ​how to communicate and resolve our‍ differences quickly, and that understanding makes our bond even stronger.

**Rebecca:** I agree! We may bicker, but at the⁤ end of the day, we truly have each other’s backs. No one knows me like Melissa does, and I ‌wouldn’t trade that‌ for anything.

**Interviewer:** Thank you both for sharing your story! It’s wonderful to see how your relationship and love for⁣ soccer intertwine. Best of luck for the rest of the season!

**Rebecca and Melissa:** Thank you! We’re excited for what’s to come!

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