Parkinson’s Breakthrough: Weekly Injection Promises to Revolutionize Treatment

A groundbreaking innovation in Parkinson’s disease therapy is on the horizon, promising to transform patient care from multiple daily doses to a single weekly injection.Developed by researchers at the University of South Australia (UniSA), this novel long-acting injectable system aims to significantly reduce the fluctuations in drug concentration that often plague current Parkinson’s treatments, thereby mitigating associated risks and improving patients’ quality of life.

The innovative formulation, which has been filed for an Australian patent, utilizes a sophisticated combination of FDA-approved biodegradable polymers. Poly(lactic-co-glycolic acid) (PLGA), known for its biocompatibility and biodegradability, is expertly blended with Eudragit L-100, a pH-sensitive polymer. this specific combination ensures a controlled and sustained release of the essential Parkinson’s medications, levodopa and carbidopa.

Extensive laboratory testing has provided strong evidence of the system’s efficacy and safety. Crucially, over seven days, the injectable achieved a remarkable release of more than 90% of the levodopa dose and over 81% of the carbidopa dose. Furthermore, the implant demonstrated excellent biodegradability, with over 80% degradation within a week, and exhibited no meaningful toxicity in cell viability assessments. The management process itself is designed for patient comfort, requiring only a fine 22-gauge needle and eliminating the need for surgical implantation.

Professor Sanjay Garg, a lead researcher on the project, highlighted the profound implications of this advancement.”By reducing the frequency of dosing from multiple times a day to a weekly injection is a major step forward in Parkinson’s therapy. We’re not just improving how the drug is delivered; we’re improving patients’ lives,” he stated. The potential of this technology extends beyond Parkinson’s, with researchers suggesting its adaptability for a wide range of chronic conditions, including cancer, diabetes, other neurodegenerative disorders, pain management, and chronic infections requiring long-term drug delivery.

the tunable nature of the system allows for drug release periods to be adjusted, ranging from a few days to several weeks, depending on the specific therapeutic requirements. UniSA scientists are actively pursuing clinical trials and exploring commercialization opportunities to bring this life-changing treatment to patients quickly.

The research underpinning this development is detailed in the study titled “Development of an in-situ forming implant system for levodopa and carbidopa for the treatment of Parkinson’s disease,” authored by Professor Sanjay Garg, Deepa Nakmode, Dr Sadik Abdella, and Dr Yunmei Song.

For further information or interviews,Professor Sanjay Garg can be reached at [email protected]. Media inquiries can be directed to Candy Gibson at [email protected] or +61 434 605 142.

What are the primary limitations of current Parkinson’s disease treatments like levodopa and DBS?

weekly Injection Shows Promise for Transformative Parkinson’s Treatment

Understanding the Current Landscape of Parkinson’s Disease Management

Parkinson’s disease, a progressive neurodegenerative disorder, affects millions worldwide. Current treatments primarily focus on managing symptoms – tremors, rigidity, slow movement (bradykinesia), and postural instability – rather than halting or reversing the disease’s progression. Common approaches include medication like levodopa,dopamine agonists,and,in some cases,deep brain stimulation (DBS). However, these methods often come with limitations, including diminishing effectiveness over time and potential side effects.The search for disease-modifying therapies remains a critical area of research. Diagnosing Parkinson’s can sometimes be challenging, and doctors may use a trial of Parkinson’s medications to assess improvement in symptoms as a diagnostic tool [1].

The Novel Weekly Injection: A Potential Breakthrough

Recent clinical trials are generating excitement around a new investigational treatment for Parkinson’s disease: a weekly injection designed to deliver therapeutic proteins directly to the brain. While still in the research phase, early results suggest this approach could offer significant benefits for individuals living with the condition.

How Does the Injection Work?

The injection contains a modified protein that aims to address the underlying causes of Parkinson’s, specifically the loss of dopamine-producing neurons. Dopamine is a crucial neurotransmitter responsible for controlling movement, and its depletion is a hallmark of the disease. The injected protein is designed to:

Protect existing dopamine neurons: Shielding them from further damage and degeneration.

Promote neuronal growth: Encouraging the regeneration of dopamine-producing cells.

Reduce alpha-synuclein aggregation: Alpha-synuclein is a protein that clumps together in the brains of people with Parkinson’s, contributing to neuronal dysfunction.

Early-Stage parkinson’s Patients: Individuals recently diagnosed with the disease may experience the greatest benefit, as more dopamine neurons are still present.

Patients Experiencing Motor Fluctuations: Those with unpredictable “on” and “off” times may find the injection helps stabilize their symptoms.

Individuals Seeking Disease-Modifying Therapies: This injection represents a potential step towards treatments that address the underlying disease process, rather than just managing symptoms.

The Future of Parkinson’s Treatment: Beyond the Injection

this weekly injection is just one piece of the puzzle in the ongoing quest to conquer Parkinson’s disease. Other promising avenues of research include:

Gene Therapy: Introducing genes into the brain to restore dopamine production.

Stem Cell Therapy: Replacing damaged dopamine neurons with healthy new cells.

Immunotherapy: Harnessing the power of the immune system to clear alpha-synuclein aggregates.

Improved Diagnostic Tools: Earlier and more accurate diagnosis is crucial for effective treatment.

Practical Tips for Managing Parkinson’s Disease Today

While awaiting potential new treatments, individuals with Parkinson’s can take steps to manage their symptoms and improve their quality of life:

regular Exercise: Physical activity can help maintain motor function and improve overall health.

Healthy Diet: A balanced diet rich in antioxidants and fiber can support brain health.

Medication Adherence: Taking medications as prescribed is essential for symptom control.

Support Groups: Connecting with others living with Parkinson’s can provide emotional support and practical advice.

Speech Therapy & Occupational Therapy: These therapies can help address specific challenges related to speech, movement, and daily living activities.

[1] Mayo Clinic. Parkinson’s disease – Diagnosis and treatment*. https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062. Accessed 2025-07-14.