Eric Dane, best known for his role as Dr. Mark Sloan, nicknamed “McSteamy,” on the long-running medical drama Grey’s Anatomy, has died at the age of 53. The actor passed away following a battle with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, according to multiple reports. Dane’s death marks a significant loss for the entertainment industry and highlights the devastating impact of ALS.
Dane revealed his ALS diagnosis in April 2025, sharing the news with People magazine. His career spanned decades, encompassing television and film, but he achieved widespread recognition for his portrayal of the charismatic surgeon on Grey’s Anatomy. Beyond his on-screen persona, Dane became an advocate for ALS awareness, using his platform to raise awareness and funds for research into the disease. The actor’s commitment to finding a cure continued even as his health declined.
A Career Cut Short by ALS
Born in California, Dane began his acting career in the 1990s, appearing in series such as California High School, Saved by the Bell: The Modern Class, and Charmed. He joined the cast of Grey’s Anatomy in 2005, quickly becoming a fan favorite. After departing the series in 2012, he took on the lead role of Captain Tom Chandler in the post-apocalyptic drama The Last Ship. More recently, Dane appeared in the HBO series Euphoria, beginning in 2019, and had a role in the drama series Brilliant Minds in October 2025. His film credits include X-Men: The Last Stand, Marley &. Me, Valentine’s Day, and Bad Boys: Ride or Die.
According to a statement released by Dane’s publicist, Melissa Bank, and cited by WRAL and PBS, he spent his final days surrounded by loved ones, including his wife and daughters, Billie and Georgia. Representatives confirmed that ALS was the cause of death.
Advocacy and a Final Role
Following his diagnosis, Dane spoke openly about his experience with ALS, including the challenges he faced. In a June 2025 interview with BBC, he described losing the ability to move his right arm but expressed a determination to continue fighting the disease. He actively campaigned for the reauthorization of legislation supporting ALS research and patient care in Washington D.C. Dane also took on a role in Brilliant Minds, portraying a firefighter secretly battling ALS, a performance that resonated deeply given his personal circumstances.
Dane had announced plans to write a memoir, titled Book of Days: A Memoir in Moments, sharing his reflections on life and his journey with ALS. His publisher, Maria Shriver, expressed her grief on X (formerly Twitter), describing his fight as “heroic” and noting his desire to leave a lasting legacy for his family.
Tributes from Colleagues
Fellow actors have shared their condolences and memories of Dane. Patrick Dempsey, who played Derek “McDreamy” Shepherd alongside Dane on Grey’s Anatomy, described him as “the funniest” and a joy to work with in an interview with Virgin Radio UK. Kevin McKidd posted “Rest in Peace, Buddy” on Instagram, while Kim Raver praised his “perfect comedic timing.” Ashton Kutcher, a co-star in Valentine’s Day, urged continued support for ALS research on X, writing, “I miss you, Buddy. Let’s continue to fight ALS.” Alyssa Milano, who worked with Dane on Charmed, remembered his “sharp wit” and recounted how he encouraged her to adopt a pixie haircut and get a nose piercing.
Eric Dane’s passing serves as a stark reminder of the relentless progression of ALS and the urgent require for continued research and support for those affected by this devastating disease. The ALS Association continues to advocate for increased funding and access to care for individuals living with ALS and their families. The impact of his advocacy and his final creative endeavors will undoubtedly continue to inspire others.
As the entertainment industry mourns the loss of Eric Dane, his legacy as a talented actor and a courageous advocate will endure. His story underscores the importance of raising awareness and finding effective treatments for ALS, a disease that affects thousands worldwide. We encourage readers to share their memories of Eric Dane and to support organizations dedicated to ALS research and patient care.
Disclaimer: This article provides information about a medical condition and should not be considered medical advice. Please consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.