The SOAR Study: Improving Mental Health and Substance Use Outcomes in Ohio

Led by principal investigator Dr. K. Luan Phan, the ambitious multi-generational study tackles rising rates of opioid overdoses, suicides, and substance use disorders across Ohio.

In recent years, public health data has underscored an urgent mental health crisis across the state. Furthermore, the Centers for Disease Control and Prevention estimates that excessive alcohol use causes over 5,700 deaths annually in the state, spanning conditions from liver disease to suicide. According to the Ohio Department of Health, suicide claims five lives every day, making it the second-leading cause of death for individuals aged 10 to 34 in 2021. To counter these sobering metrics, the Ohio State Wexner Medical Center serves as the lead research site for the SOAR Study, which aims to shift away from traditional, siloed research models toward an integrated, community-wide approach.

In Plain English: The Clinical Takeaway

• Multi-Gen Approach: The study evaluates both biological brain function and environmental social factors across multiple generations to help families break cycles of mental illness and substance dependence.
• Dual-Track Design: Research operates via two parallel tracks—the Wellness Discovery Survey targeting 15,000 participants and the Brain Health Study following 3,600 members across 1,200 families.
• Early Intervention Focus: By mapping how biology, lifestyle, and environment interact, clinicians intend to spot vulnerabilities earlier and prevent the onset of severe psychiatric conditions.
• Comprehensive Scope: Investigators examine individuals who are struggling alongside those who have successfully navigated past adversity, building one of the most diverse health databases of mental health research.

Unpacking the Dual-Track Research Methodology

Structured to provide an expansive, data-driven foundation, the SOAR Study relies on two interrelated projects conducted simultaneously. The SOAR Wellness Discovery Survey gathers social, psychological, and real-world experiential data from approximately 15,000 Ohioans. Simultaneously, the SOAR Brain Health Study captures biological, brain function, psychological, and environmental measurements from roughly 3,600 individuals across 1,200 Ohio families. This dual-track strategy bridges individual biology with broader community contexts.

Persistent stress remains a primary catalyst for substance use, unintentional drug overdoses, and suicide. By evaluating participants from diverse backgrounds—including resilient individuals who have adapted well to past trauma—the scientific leadership team hopes to uncover protective factors. Dr. K. Luan Phan, professor and chief of psychiatry services holding the Jeffrey Schottenstein Endowed Chair of Psychiatry and Resilience, oversees the initiative alongside a multidisciplinary team. This leadership group features Anthony King, PhD, the Anne K. “Nancy” Jeffrey Endowed Professor for Mental Health Equity and Resilience, and Dr. Nina Kraguljac.

Regional Healthcare Integration and Public Access

Patients seeking guidance or wishing to participate in ongoing health registry efforts can contact the study team directly at 614-688-9537 or via email at [email protected].

Photo: medicine.osu.edu

SOAR Study Component	Target Sample Size	Primary Data Collection Focus
SOAR Wellness Discovery Survey	Approximately 15,000 Ohioans	Social makeup, psychological status, and real-world mental health experiences.
SOAR Brain Health Study	Approximately 3,600 members (1,200 families)	Biological and brain function data alongside psychological and social environments.

Contraindications & When to Consult a Doctor

Anyone exhibiting active suicidal ideation, severe substance withdrawal symptoms, or acute psychiatric crisis should not wait for community study findings. Immediate assistance is available through professional medical channels, local emergency departments, or the nationwide Suicide & Crisis Lifeline by dialing 988.

Patients currently managing mental health disorders should consult their attending physician, psychiatrist, or licensed clinical psychologist before altering any prescribed therapeutic regimens. Clinical diagnoses require comprehensive, individualized evaluation rather than generalized public health data.

References

• Centers for Disease Control and Prevention (CDC). National Center for Health Statistics: Mortality Data and Substance Use Statistics. CDC Public Health Data
• Ohio Department of Health. Vital Statistics and Annual Report on Suicide and Overdose Trends. Ohio Department of Health
• NIH Scientific Resources
• The Ohio State University College of Medicine. SOAR Study Program Overview and Clinical Trials Directory. Ohio State Wexner Medical Center

Disclaimer: This article is intended for informational and educational purposes only and does not substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified mental health provider with any questions regarding a medical condition.