‘TIP1 peptide’A study has found that this substance can treat systemic lupus erythematosus, an autoimmune disease..
Department of Rheumatology, Ajou University Hospital Professor Chang-hee Seo’s team published the results of this study in an international scientific journal. <International Journal of Molecular Sciences> in the latest issue “Tall-like receptors(Toll-like receptor, TLR) Signal transduction inhibitory peptide improves inflammation in animal models of systemic lupus erythematosus and patients with systemic lupus erythematosus”published as a thesis with the.
According to him, Tall-like receptors are very important substances to recognize external pathogens and activate the immune response.. However, when the toll-like receptor is overexpressed, the immune response is excessively increased, which is an autoimmune disease in which the body attacks itself.(Lupus, etc.)can cause.
In order to prevent overexpression of the tall-like receptor, the research team combined a substance that can inhibit the protein that is activated in the signal transduction process of the tall-like receptor and a substance that allows it to be delivered well into the cell. TIP1 developed a peptide.
Also, the research team TIP1 In order to confirm the inhibitory effect of the peptide on the tall-like receptor, a representative lupus animal model MRL/lpr on the mouse TIP1 Peptide treated.
As a result, clinical symptoms of lupus in mice(skin symptoms, enlarged lymph glands and spleen)and disease markers(autoantibodies, complement, urine proteinuria, etc.) It was confirmed that the level has improved. kidney, In major tissues, such as the spleen and lymph nodes, signaling molecules involved in the expression of Toll-like receptors TLR7&9, MyD88, IRF7 It was confirmed that inflammation was improved as the protein decreased.
In real lupus patients TIP1 In order to confirm the effect of the peptide, we cultured monocytes in the patient’s peripheral blood and TIP1 Peptide treatment results, It was confirmed that the toll-like receptor-expressing signaling protein and interferon alpha, a cytokine that plays an important role in the pathogenesis of lupus, decreased..
both in animal models and in patients with lupus TIP1 It was confirmed that the peptide could obtain the effect of improving the inflammation of lupus by inhibiting the signal of the toll-like receptor..
Professor Seo Chang-hee “There are many different causes of inflammation due to lupus.. This study ‘TIP1 peptide’It is significant in that it was first confirmed that Garlic is a new substance that can be expected to improve inflammation in lupus.. It is hoped that this substance will be developed as a therapeutic agent and will be helpful in the treatment of lupus patients.”said.