2024-03-20 23:05:47
“Lymphocytes” are distributed throughout the human body, and lymphoma may occur in any organ in the body, with more than half of them originating from lymph nodes (Lymph nodes). There are over a hundred types of lymphoma, which are roughly divided into two categories: Hodgkin lymphoma and Non-Hodgkin lymphoma. The latter includes slow-growing cancer cells. “Low grade lymphoma” (Low grade lymphoma), such as “Follicular lymphoma” (Follicular lymphoma), or “High grade lymphoma” (High grade lymphoma) with rapidly growing cancer cells, such as “Diffuse Large B Cell Diffuse large B cell lymphoma.
60-year-old Mr. Wang found that his left cervical lymph node was swollen. A PET/CT scan showed swollen lymph nodes all over the body and rapid cell growth. A biopsy confirmed that he had diffuse large B-cell lymphadenitis. “Cancer”; “Bone marrow biopsy” showed no cancer cells, indicating it was in the third stage. The doctor prescribes the standard R-CHOP regimen, which includes the anti-B cell CD20 monoclonal antibody “Rituximab” and three chemotherapy drugs: “Adriamycin”, “Vincristine” and “Cyclophosphate” “Cyclophosphamide” (Cyclophosphamide), and adding steroids at the same time, the chance of cure is high. If lymphoma cells have c-myc, bcl-2, or bcl-6 gene mutations, the toxicity will be higher. You can consider switching to the DA-EPOCH-R regimen, which also includes “rituximab” and “doxorubicin” , “vincristine” and three chemotherapy drugs and steroids; the dose of chemotherapy was larger, and an extra chemotherapy drug “Etoposide” was added. Some chemotherapy drugs required 24-hour intravenous drip for four consecutive days. “Polatuzumab” targets the CD79b protein of B cells and can replace the chemotherapy drug “vincristine” in the R-CHOP or DA-EPOCH-R regimen.
The human body’s “Central nervous system” has a protective barrier (Blood brain barrier). The chemotherapy drugs in the R-CHOP and DA-EPOCH-R regimens cannot penetrate into the brain and spinal cord, so they cannot effectively remove the blood brain barrier. Lymphoma cells within the central nervous system. High-risk patients must receive intensive treatment, including intravenous injection of large doses of “Methotrexate”, which can penetrate into the brain and spinal cord, and then use “Folinic acid” as an antidote to reduce side effects. “Intrathecal methotrexate” is another option. It injects “methotrexate” directly into the “Cerebrospinal fluid” (Cerebrospinal fluid), with the goal of reducing the chance of lymphoma recurrence in the “central nervous system” .
(This column is published every other Thursday)
Written by: Dr. Liang Xiansu, Hematologist and Hematology Oncologist
Column name: Medical Qing’s medical sentiment
-
Elderly Falls | 76-year-old Qin Huang, who lives alone in a Tsing Yi hotel, fell twice and was admitted to the hospital. Doctor reveals the reasons why elderly people often fall + 5 tips to prevent falls
-
The Voice of Middle Ages 2 | Miriam Yeung was involved in the final judging controversy and was dragged into the water. Ng Chung-heng: Without common sense, I first thought that judging should know how to sing.
-
Weight Loss Battle｜A 187-pound stay-at-home mother lost 70 pounds in 4 months and shared 6 tips on weight loss[with 7-day meal plan]
-
Food safety｜CCTV revealed that the raw material of Mainland black-hearted pickle pork is actually inferior lymph meat and contains a large number of lymph node lipoma
-
Tang Luowen’s beloved cat nearly died of allergies after being vaccinated, and she was heartbroken and burst into tears: she considered tying the cat and continuing to vaccinate her
-
Qin Huang’s feet were swollen and he fell down many times and was unable to get up and was sent to the hospital. Lin Wei called on his children to visit: the family must make the decision first
-
Make your own long-term income by back-depositing your insurance policy | Ample retirement reserves + protect your family’s GET! (Attach case description)
-
New HPV-related head and neck cancers rising in men at higher risk
-
【Ruo Shan talkative】The edge of love and pain
-
Chest tightness, head swelling, numbness of hands and feet?Huang Xiangxing removed the blood vessel bomb and regained consciousness and health without relying on drugs for one month
-
Grace’s advice for itching, burning, and odor in the private parts: 1 tablet a day to solve “private” problems
-
Long-acting insulin helps diabetics maintain stable sugar control. Doctors dismantle myths about insulin injections
-
Not only yellow face but acne, long-term scratching may lead to liver damage. Huang Xiangxing reversed liver function. Fortunately, he protected his liver as soon as possible.
-
Losing control of blood sugar can hurt your heart!
You may also like…
-
Lack of vitamin B12 and folic acid
-
Bone marrow failure caused by bone marrow disease
Diffuse large B-cell lymphoma – Qingbao – Life Supplement – Column – D240321
Diffuse large B-cell lymphoma – Qingbao – Life Supplement – Column
“Lymphocytes” are distributed throughout the human body, and lymphoma may occur in any organ in the body, with more than half of them originating from lymph nodes (Lymph nodes). There are over a hundred types of lymphoma, which are broadly divided into Hodgkin’s lymphoma
https%3A%2F%2Fskypost.hk%2Fcolumn%2Farticle%2F3727742%2F%E7%80%B0%E6%BC%AB%E5%A4%A7B%E7%B4%B0%E8%83%9E%E6% B7%8B%E5%B7%B4%E7%99%8C
life supplement
Column
514
3727742
503
503007035
life supplement
com.hket.sp.model.v2.FormalTag@73884233 com.hket.sp.model.v2.FormalTag@b270737 com.hket.sp.model.v2.FormalTag@558f5304
healthy
1710998251
#Diffuse #large #Bcell #lymphoma #Qingbao #Life #Supplement #Column