2023-08-14 03:29:00
medical genome center Faculty of Medicine Ramathibodi Hospital Facebook post Center for Medical Genomics To the mutation of the Omicron strain of COVID This is the latest strategy of new viruses GK (XBB.1.5.70) and HK to evade immunity and bind to the cell surface better than XBB and Aeris “EG.5” by mutating. Flip combo mutation
The WHO has declared the Eris strain of COVID-19 a strain of concern.
The Genome Center reveals that “EG.5.1” cannot replace “XBB.1.16” in Thailand.
Scientists have found that COVID has a new strategy (New trick) as evolution for survival. Natural immunity from vaccination and infection can be evaded. Better adhesion to the cell surface, called “Flip”, that is, there are two adjacent mutations. A bipolar double/combo mutation, L455F and F456L, caused changes at the amino acid level. “phenylalanine (F)” and “leucine (L)”, with the first mutant loci flipped from L to F and the subsequent loci from F to L. Combining the two changes, Together, the viral spikes evade immunity and bind more tightly to the cell surface (ACE2), allowing for better viral infiltration. This phenomenon was called A flip combo mutation has given rise to two new XBB variants.
GK, or XBB.1.5.70, originates from XBB.1.15, mutating on two adjacent spines, L455F and F456L, and HK.3 or XBB.1.9.2.5.1.1.3. Originated from EG.5.1, there are mutations on two adjacent spines, L455F and F456L.
Omicron with high flip combo mutation was found in “Brazil”. “Spain” was not found in Thailand. It is expected that these two strains will endemic in the future to replace the original XBB, including EG.5.1. near
Features of “Super Variant”, a mixed strain of COVID, has gone viral in America
from the mutation of COVID-19 The relentless push forward led the US Food and Drug Administration to say in June 2023 that vaccination in late 2023-early 2024 should use a single strain vaccine, or “Monovalent” omicrons targeting at least the XBB substrains XBB.1.5, XBB.1.16 or XBB.2.3 to keep pace with the forward mutation of COVID-19. Without adding the original strains such as Wuhan, Alpha, Beta, Gamma, Delta, Omicron-BA.1,BA.2,BA.4,BA.5. It was added to the vaccine because there was no scientific evidence to suggest that the previous Omicron XBB strain would re-emerge.
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