2023-06-22 18:17:08
What is FKBP51?
FKBP51 is a protein, more specifically a protein molecule, that occurs in our body. It belongs to the group of FK506-binding proteins and plays an important role in various biological processes. FKBP51 is best known for its Functions in the area of the stress system, energy metabolism and the regulation of inflammatory reactions.
The protein can block depression, obesity and pain
Researchers now have a new approach to drug development:
In the stress system, FKBP51 influences the action of stress hormones. It interacts with the so-called glucocorticoid receptor and can modulate its activity. As a result, FKBP51 can be used both in the body’s stress reactions and in the development of stress-related diseases, such as Depressions, play a role.
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In addition, FKBP51 has also been linked to the Energy metabolism and obesity examined. It influences the metabolism of glucose and fat and can therefore influence body weight and energy balance. Changes in FKBP51 levels have been observed in obese individuals, suggesting that the protein may be involved in the development and regulation of obesity.
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Also at chronic pain FKBP51 could play a role. It is assumed that the protein is involved in the regulation of pain receptors and the conversion of pain signals, which can have an impact on the development and maintenance of chronic pain conditions.
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What’s next for the pain molecule FKBP51?
The research project of the TU Darmstadt was funded by the federal government with a total of 369,502 euros and runs for three years from 2020 to 2023. During the investigations, a number of different inhibitors are used to try to down-regulate the pain protein FKBP51. If the researchers succeed in activating or deactivating the molecule with specific inhibitors, the way could be cleared for subsequent preclinical studies.
In the long run could Drugs with potent inhibitors are developed that down-regulate chronic pain in humans. New drugs for depression or obesity are also conceivable.
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#protein #block #depression #obesity #pain