2024-04-12 19:32:37
But the main “new thing” is this correlation between a person’s age, gender and location
and its risk of antibiotic-resistant blood infections. Its implications are crucial given the major global threat that AMR poses to public health.
Peaks of resistance at the youngest and oldest ages
The study analyzes data from 944,520 participants from 29 European countries, collected as part of routine surveillance between 2015 and 2019 on blood infections. The British team looked at which bacterial species had been isolated and sent to surveillance services, and which antibiotics had been used to treat these infections. The analysis reveals:
- distinct patterns of resistance prevalence by age, across Europe, varying according to bacterial species;
- for most bacteria, but not all, peaks in resistance are observed at the youngest and oldest ages;
- the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) increases with age and the occurrence of aminopenicillin resistance with Escherichia coli decreases with age;
- some AMR profiles peak in middle age: Pseudomonas aeruginosa around age 30 and, in women, E. coli peaks between ages 15 and 40;
- Significant differences are observed between the sexes: in general, men have a higher risk of antimicrobial resistance than women.
These findings, that the prevalence of resistance in bloodstream infections across Europe varies significantly by age and sex, highlight significant gaps in our knowledge of the epidemiology of antimicrobial resistance et suggest useful consideration of better targeted interventions to reduce the burden of AMR.
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