On 4 May 65, Dr. Anan Chongkaewwatana, a virologist Director of Animal Health and Management Innovation Research Group National Center for Genetic Engineering and Biotechnology (Biotech), National Science and Technology Development Agency (NSTDA) posted a message via Facebook Anan Jongkaewwattana stated that …
One study was published by a large research team in China. An in-depth study of the immune escaping of the new omicron virus BA.4/5 against BA.2.12.1, which is soon becoming a major strain in the United States. The content and information of the research is a lot. Let me tell you about the point that I think is interesting and explain it in simple language first.
The first point is It is suspected that we have vaccinated several injections of the original strain. and then suddenly get infected with the first omikron, which is BA.1. How much immunity after infection should we have immunity to omikron? To what extent does the memory in which we inoculate the older strains affect the immunity specific to the omikron? The team answered this question by looking at memory B cells, white blood cells that make antibodies to spike proteins. In the sample group, 3 groups were: 1. People infected with BA.1 after immunization from the vaccine, 2. People who have been vaccinated with Sinovac but have never been infected, and 3. People who have not been vaccinated and infected with BA. .1 It can be seen that the latter two groups are the controls whose memory B cells must produce different antibodies, group 2 producing only vaccine strain-specific antibodies, and Group 3 producing antibodies against omikron. While the first group is the group that is interested in what will happen.
What the researchers found was that the amount of memory B cells in group 1 was significantly higher than in the latter two groups and that it was at that high level for at least two months after recovery when those memory B cells were attached to the spike. of which species The results showed that about 80% produced antibodies against the portion of the vaccine spike and omikron in common, while only 20% went on to specifically bind to the portion of the mutated omikron. This means that if an antibody that will protect against infection with a strain different from the original Wuhan is needed, only 20% are likely to be able to catch it, because 80% of the virus triggered by the virus comes from the known antibody. The vaccine teaches the body to recognize over and over again. The more often it is repeated, the more difficult it will be to be stimulated by something new.
The data here, therefore, are consistent with the ability of BA.1 to induce immunity from the vaccine by 20%, which appears to be sufficient to suppress re-infection from BA.1 and possibly BA.2 if BA.2 mutation is present. A little more such as L452R in BA.4/5 or L452Q in BA.2.12.1, you will see that the 20% provided by BA.1 is rarely needed. It’s quite clear that Change 452 in BA.2 in many places like this. It is the process by which the virus escapes from the human population, and this is certainly not the last card of the virus because endemic disease is a disease that does not go away. But we have to live with him.
https://assets.researchsquare.com/…/v1_covered.pdf…