2023-11-21 08:17:25
An unexpected relationship between visceral abdominal fat and Alzheimer’s disease was revealed by a recent study, which indicated that the accumulation of fat around internal organs, even for people with a healthy body mass index, is linked to changes in the brain.
A study published during the annual meeting of the Radiological Society of North America indicated that people who have large amounts of fat stored around their organs may be more susceptible to developing Alzheimer’s disease as they age.
Visceral fat has previously been associated with systemic inflammation and high insulin levels, both of which are thought to be involved in the development of Alzheimer’s disease, according to the study’s lead author, Dr. Cyrus Raji, a neuroradiologist at Washington University School of Medicine. In St. Louis.
Experiment on 54 volunteers
In addition, to take a closer look at the potential impact of visceral fat on the risk of Alzheimer’s disease, Raji and his colleagues analyzed data from 54 volunteers aged 40 to 60 years who had an average body mass index of 32, according to NBC News.
The researchers measured a range of health parameters, including insulin and blood sugar levels. Using MRI scans, they assessed the amount of fat just under the skin as well as what surrounded the organs.
MRI has also been used to measure the thickness of the outer layer of the brain, which is responsible for functions such as speech, perception, long-term memory and judgement, and which becomes thinner as Alzheimer’s disease progresses.
More fat, more amyloid
The researchers found that participants with more visceral fat had greater accumulations of amyloid in their brains, suggesting they may be more susceptible to developing Alzheimer’s disease.
While Raji stressed that previous research has shown that inflammation and high insulin levels, which can inhibit proteins that break down amyloid in the brain, are linked to visceral fat.
Because the early development of Alzheimer’s disease in the brain can begin up to 20 years before the first symptoms appear, the researchers plan to study the potential long-term impact of visceral fat by following study participants.
Alzheimer’s discovery
It is noteworthy that Alzheimer’s disease was discovered by Dr. Alius Alzheimer’s in 1906, who noticed changes in the brain tissue of a woman who died of an unusual mental illness.
Doctors usually diagnose Alzheimer’s disease when they find a combination of amyloid plaques and neurofibrillary tangles, along with dimensions.
The abnormal buildup is known to cause Alzheimer’s disease, which involves two types of proteins: one called amyloid, whose deposits form plaques around brain cells, and the other called tau, which forms tangles inside brain cells.
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