Vitamin D and P53 Protein: The Key to Reducing Cancer Risk

2023-11-05 23:15:44

A recent study published by Boston University School of Medicine in the United States showed that there is a significant relationship between vitamin D and the P53 tumor suppressor protein in the human body. Therefore, adequate intake can reduce the risk of cancer.

In medical research over the past century, a large amount of literature has shown that lack of sunlight exposure and vitamin D will increase the risk of various cancers, including breast cancer, prostate cancer, and colorectal cancer. However, for many years, there has still been a direct relationship between lack of vitamin D and cancer. Therefore, many scholars disagree with this conclusion.

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A recent research article published by a team at Boston University School of Medicine in the United States pointed out that because there is a gene called P53 in the human body, the P53 tumor suppressor protein produced by the P53 gene can inhibit the mutation of human cells. Therefore, cancer cells cause mutations in the P53 gene. The body’s mechanism to suppress cell canceration is destroyed, allowing more cancer cells to proliferate and making certain cancer treatments ineffective.

However, a research team led by Dr. Michael F. Holick found that sufficient vitamin D can reduce the chance of the P53 gene being affected by cancer cells, because vitamin D can reduce the chance of P53 protein mutation.

During the research process, the team observed that many cancer patients whose immune systems had resisted and produced antibodies against the mutated P53 protein found that if the patients took 2,000IU of vitamin D3 daily, their survival rate was nearly higher than that of patients who did not. 2.5 times.

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However, for patients whose immune systems do not yet have antibodies against the mutated P53 protein, taking vitamin D will not increase their chances of survival.

He Like pointed out that the future research direction will focus on the correlation between P53 antibodies and breast cancer, prostate cancer, colorectal cancer and other cancer cells, and design a method to detect the concentration of P53 antibodies in the human body to further explore the relationship between vitamin D and Interactions between various cancer cells.

The team’s research results have been published in JAMA Network Open.

(First image source: Shutterstock)

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