2023-07-03 04:11:37
▲ Courtesy of the University of Maryland, Baltimore
A patient in his 50s, who received the world’s first genetically engineered pig heart transplant, died in just two months in March last year, and the Maryland Rae Medical Center belatedly disclosed the cause of his death. On the 2nd (local time), Maryland Rae Medical Center announced in the medical journal ‘The Lancet’ that the cause of the operation failure was the death of David Bennett, then 57, of worsening heart failure.
He, who did not show an acute rejection reaction for the first few weeks immediately after the transplantation surgery, died suddenly of heart failure two months later, and the research team explained that various studies were conducted for a long period of time regarding his death. Dr. Muhammad Muhyiddin and Dr. Bartley P. Griffiths, professor of surgery at the University of Maryland School of Medicine and director of the Cardiac Xenotransplantation Program, found that transplant patients suffered extensive endothelial damage, which was strongly rejected by antibodies. interpreted that
The research team said, “Especially, the patient’s transplant surgery immune system was severely damaged, so the use of the treatment regimen used for general patients was limited.” He added, “We used immunoglobulin intravenous injection twice after surgery, and this ruled out the possibility that it caused heart cell damage. I can’t do it,” he analyzed.
In addition, an unexpected porcine cytomegalovirus was found in the transplanted heart of Bennett, who died, and it was highly likely that this acted as a cause of death such as organ dysfunction. The presence of the virus was unexpected because the pigs used in the xenotransplantation were rigorously reared in sterile facilities. However, the investigation found no evidence that the virus had spread to organs other than Bennett’s heart, the team added.
In this regard, Dr. Bartley P. Griffiths of the University of Maryland, who performed the transplant surgery, said, “The research team has shown that the next transplant patient can not only survive longer than before, but also live a normal life for at least a few months to a few years. I hope there will be.”
Meanwhile, on January 7, a research team from the University of Maryland Medical Center performed a genetically engineered pig heart transplant with the consent of Bennett, who was living a terminal life with no other options as he was a patient with end-stage heart failure and had no other options. proceeded
However, at the time of the sudden death of the patient in March, the research team did not reveal the exact cause of death, saying, “It is not clear whether his death was due to organ rejection.”
Correspondent Lim Ji-yeon [email protected]
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