???? Hydroxyurea - Definition and Explanations

2023-11-19 19:31:29

Introduction

Hydroxyurea General CAS No. 127-07-1 EINECS No. 204-821-7 ATC Code L01XX05 SMILES InChI Chemical properties Crude formula CH4N2O2
Mass (The term mass is used to designate two quantities attached to a…) molar 76.0547 ± 0.0021 g·mol-1 Physical properties Melting temperature (In physics and metallurgy, fusion is the passage of a body from the solid state to the state…) 141 °C Precautions IARC Classification Group 3: Unclassifiable as to its carcinogenicity for humans (A man is an adult male individual of the species called Man modern (Homo…) Units of the SI & CNTP, unless otherwise indicated.

Hydroxyurea, or hydroxycarbamide (CH4N2O2) was first synthesized in 1869, but interest in this product in leukemia only developed during the 1960s.

Hydroxyurea differs from urea by the presence of a hydroxyl group on one of the atoms (An atom (from the Greek ατομος, atomos, “that we cannot…) of nitrogen (Nitrogen is a chemical element of the pnictogen family, with the symbol N and…).

This molecule (A molecule is an electrically neutral chemical assembly of at least two atoms, which…) acts on ribonucleotide reductase. This is the key enzyme in the transformation of the four ribonucleotides into deoxyribonucleotides essential for DNA synthesis.

Hydroxyurea is a particularly important molecule involved in the treatment of sickle cell or sickle cell anemia. drepnos, sickle), also called hemoglobinosis…). Indeed, it will stimulate the synthesis of fetal hemoglobin (HbF) composed of 2 alpha chains and 2 gamma chains. This will make it possible to compensate for the mutation occurring in the beta chain during sickle cell anemia. Thus, the transport of oxygen (Oxygen is a chemical element of the family of chalcogens, etc.) occurs normally and the risk of anoxia linked to sickle cell anemia is limited. At larger doses, hydroxyurea is used in onco-hematology, particularly in the treatment of myelo-proliferative syndromes.