On Thursday, January 26, Fr. Konrad Malys OSB commented on chapters 24-28 of the Rule of St. Benedict at a meeting of oblates, and on Saturday, January 28, he led the Warsaw Benedictine Meeting, during which he gave a conference on The unity of way, truth and life in the Rule of St. Benedict.
Daily Archives
February 6, 2023
The market for one or more drugs once morest Alzheimer’s disease is immense. And yet, it seems very difficult to develop a molecule that can block the evolution of the disease. The rare treatments marketed to date have not been lucky. They were either withdrawn or withdrawn from the market for inefficiency. “The problem is that when you don’t know a disease very well, it is difficult to find a treatment,” says Professor Philippe Amouyel. And then from the moment the disease is diagnosed, it is often already evolving for a long time and the destruction of neurons is irreversible. »
Alzheimer’s disease is characterized by a loss of neurons, with an accumulation of so-called “amyloid” protein plaques in the brain and neurofibrillary degeneration. It begins with the accumulation of this amyloid protein. But is this accumulation cause or consequence of the disease? Does eliminating this protein also eliminate the disease? Attempts to vaccinate once morest this protein in mice suffering from a form of cerebral degeneration have shown an improvement in their condition. But the tests on human beings unfortunately ended in such serious complications that this track was abandoned.
A lead: a monoclonal antibody
A new drug once morest Alzheimer’s, lecanemab, authorized in January 2023 in the United States, is a monoclonal antibody that blocks the amyloid protein. Trial results published in November 2022 reveal that this drug decreases cerebral amyloid protein overload, assessed by imaging, in patients with early stage disease.
The effect on disorders is much less spectacular. On a scale of increasing symptoms ranging from 1 to 18, the drug made it possible to obtain, in eighteen months, a difference of 0.45 points less for treated patients compared to those who were not treated. “If we make the assumption that this effect persists in the long term, the drug following six years, might make it possible to prolong the period without dependence from sixteen to nineteen months. The biological effect is clear, the clinical effect remains moderate,” notes Professor Amouyel.
There are also side effects, 17% cerebral micro-haemorrhages, 13% cerebral oedemas. Finally, and this is not the least constraint, this treatment will probably cost per patient between 25,000 and 30,000 euros per year. The European Medicines Agency is studying the file.
Sales of this Lidl product jumped thanks to Miley Cyrus
written by Alexandra Hartman Editor-in-Chief
People and royalty
A collateral effect of the success of the singer.
For several weeks, Miley Cyrus, and her title “Flowers”, has met with dazzling success. In this resale song, released on the birthday of her ex-husband, Liam Hemsworth, the singer settles her accounts and appears stronger than ever. A title feel good, in which she affirms in particular that she can buy herself flowers, hold hands or that she can dance alone. On social networks, the song has even become a feminist ode that seems to boost women’s confidence.
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And this effect is even felt in Lidl’s sales. In fact, UK flower sales are up 52% since January 12. Sales have therefore doubled, just that, and the dates coincide with the release of the said song. There is no such thing as coincidence.
Sylvester Stallone climbs his own mountain! – Newspaper Advertising
written by Alexandra Hartman Editor-in-Chief
A horde of celebrities is once once more climbing the mountain Paramount for an announcement of Super Bowl which promotes Paramount+. But this time, the mountain itself has some words to share.
The ad features Sylvester Stallone, Dora the Explorer and Captain Pike from “Star Trek”among others, as the platform hopes to build on the momentum of the “Mountain of Entertainment” campaign that debuted during the 2021 Super Bowl.
“The campaign has been a huge driver in raising awareness for Paramount+,” said to Ad Age Domenic DiMeglio, Executive Vice President and Chief Marketing Officer of Paramount Streaming. Launched in 2021, the campaign featured numerous famous faces, including Patrick Stewart, RuPaul, Lucille Ball and SpongeBob, in its Super Bowl ad two years ago. A campaign installment starring Keegan-Michael Key in November became “Paramount+’s most successful film to date in terms of organic viewership and fan engagement.”DiMeglio said.
The media company declined to disclose which quarter the new ad would air in, but did specify that a 30-second variant of the ad (whose original version is 60 seconds) would air during the game.
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