NEW VARIANT. This sub-variant of Omicron is the majority in France. 92% of positive covid tests analyzed by Santé Publique France come from the BA.2 variant. What are its symptoms? How dangerous is it? Is it possible to be re-infected?
[Mis à jour le 8 avril 2022 à 11h13] BA.2 is a subvariant of Omicronitself a variant of Sars-CoV-2. BA.2 and responsible for the recent resumption of the epidemic. The sub-lineage BA.2 is majority in Francerepresenting 92% of positive covid tests analyzed by Public Health France according to epidemiological point of April 7. He is more contagious than the BA1 Omicron sub-variant which first appeared in France. But he does not present no more danger. “We have past the peak of the epidemic rebound a few days ago. It’s been going down for five days nowe” reassured Olivier Véran on Thursday April 7 on RTL. “I’m not saying the epidemic is behind us. I continue to tell the French to protect themselves in the period. 150,000 contaminations per day, it’s not nothing“, however, nuanced the Minister of Health. Several recent studies have highlighted the possibility of occurrence of a reinfection by BA.2 following an infection by BA.1, including within a very short period of time (less than 60 days (2 months)). What is this new mutation? of Covid-19? Is she more contagious, more dangerous, what Omicron? the vaccine effective against this new variant? What are the symptoms of BA.2 ? Update.
Definition: what is the new BA.2 variant?
“The BA.2 is a subvariant of Omicron. It is a “little cousin” of the Omicron variant“explained Jean-François Delfraissy, president of the Covid Scientific Council, at the microphone of France info in January. Named BA.2, it is a sub-lineage of Omicron like BA.1 (which circulated until now) or BA.3. “The genetic sequence of the BA.2 subvariant differs from that of BA.1 and notably shows amino acid differences in the Spike protein and other proteins” indicated theWHO in February 2022.”The most recent data appear to confirm that BA.1 and BA.2 show similar severity and immune response evasion, and therefore BA.2 is not considered a distinct variant but is included in the Omicron VOC.” specifies Public Health France. However BA.2 “is the most contagious variant of virus SARS-CoV-2 we’ve seen so far“, alerted Maria Van Kerkhove of the WHO, on March 19 at a press conference.
What is the rate of the BA.2 variant in France?
The BA.2 Omicron variant is now more present than the BA.1 variant, which has been circulating mainly since the end of 2021 in France. As of April 7, according to Public Health France, BA.2 represents 92% Omicron sequences analyzed over the week of March 21 to 27. “The progression of BA.2 to the detriment of BA.1 is observed on the whole of the metropolitan territory, but at different levels depending on the region. In the DROMs, BA.2 also seems to be increasing but the data needs to be consolidated“adds the organization.
What are the symptoms of the BA.2 variant?
For the moment, there are no specific symptoms listed on the cases of sub-variants BA.2. On the other hand for the Omicron variant “epidemiological investigations indicate a specific clinical presentation with more upper respiratory symptoms and less loss of taste and smell, as well as a lower severity (risk of hospitalization and admission to intensive care up to 80% lower)” reported Public Health France January 26. Symptoms of the BA.2 variant (like Omicron in general) can be:
- Tiredness ;
- Cough ;
- Fever ;
- Headache
- muscle aches or body aches;
- Sore throat ;
- Runny nose ;
- Nausea and vomiting
- Unpleasant breathing (more rarely)
- Loss of taste and smell (more rarely)
Is the BA.2 variant more contagious than Omicron?
“BA.2 is more transmissible than BA.1 (Secondary attack rate of 39% for BA.2 against 29% for BA.1). A study also estimates that the generation interval (time between two cases) of BA.2 is 15% lower than that of BA.1. These differences in transmissibility explain the rprogressive placement of BA.1 by BA.2 observed globally” emphasizes Public Health France on March 25. BA.2 “is the most contagious variant of the SARS-CoV-2 virus we have seen so far“, said Maria Van Kerkhove, epidemiologist at WHO, on March 19.
What are the risks of re-infection with BA2?
The frequency of possible reinfections with SARS-CoV-2 has increased significantly since the introduction and distribution in France of the Omicron variant, at the beginning of December 2021, notes Public Health France. “The upward resumption of the circulation of SARS-CoV-2 observed for several weeks in France and theemergence of the Omicron BA.2 sub-lineage, majority since week 09-2022 are two factors that may play a role in the current trend of increasing numbers of reinfections” confirms the agency. Several recent studies have highlighted the possibility of occurrence of reinfection with BA.2 following infection with BA.1, including within a very short period of time (less than 60 days). “Nevertheless they agree on the fact that these are probably rare events.”
Is the BA.2 variant more dangerous than Omicron?
“Omicron’s BA2 subvariant does not “cause a more severe form” of Covid than BA1, according to Maria Van Kerkhove, epidemiologist in charge of the emerging diseases unit at the WHO, on March 19. However, with a large number of cases, you will see an increase in hospitalizations and this will turn into an increase in deaths.…”. She specified that there is no not “difference in terms of severity between BA1 and BA2“.
“In France, the screening strategy can detect all Omicron without distinction, whether they are BA.1 or BA.2 and therefore to know in a reactive way the level of circulation of the variant” noted Public Health France. In a second time, a sequencing makes it possible to make the difference between the sub-variants, BA.1 and BA.2 “Screening makes it possible to reactively follow the Omicrons as a whole and sequencing allows a finer analysis of the different sub-lineages [BA.1 ou BA.2]“.
Are vaccines effective against the BA.2 variant?
“The efficacy of the vaccine against symptomatic disease caused by BA.1 and BA.2 is similar: after two doses the efficacy is 10% for BA.1 and 18% for BA.2, after three doses the efficacy against symptomatic disease is 69% for BA.1 and 74% for BA.2 Efficacy drops to almost 50% two and a half months after the 3rd dose for BA.1 and BA.2“according to the study by the British health agency published on February 25.”This suggests that vaccination is at least as effective in preventing acquisition of BA.2 and may be more effective in preventing transmission of BA.2 than BA.1“, remarked the WHO.”L‘vaccine efficacy is maintained against Omicron after administration of a booster dose, especially against severe forms“confirmed Public Health France on January 26.
Sources :
– “SARS-CoV-2 variants of concern and variants under investigation in England”, British Health Agency, 25 February 2022
– “Coronavirus: circulation of SARS-CoV-2 variants”, updated on February 25, 2022, Public Health France
-“BA.2 is more transmissible than BA.1 but vaccinated people are less likely to become infected and to transmit the infection”, January 31, Statens Serum Institut.
– COVID-19: epidemiological update of January 27, 2022, Public Health France
– “Risk analysis on emerging variants of SARS-CoV-2”, January 26, 2022, Public Health France.
-“Now a variant of Omicron, BA.2, accounts for nearly half of all Danish Omicron cases” January 20, 2022, Statens Serum Institut.