2023-06-13 04:00:16
With equal tobacco consumption, women would be more exposed to the risk of developing lung cancer than men. This is the worrying finding that emerges from the Cascade study, launched in April 2022, and carried out by Marie-Pierre Revel, head of the radiology department at Cochin hospital. The objective of this research is to detect this disease using a low-dose scanner in women in France.
It has just delivered the mid-term results. “The rate of positive screenings is two to three higher in women than in men. We did not expect these results at all. One in thirty participants tested positive. Our forecast was 1%, the reality is 3%. » The Belgian-Dutch firm Nelsonpublished in 2020 in The New England Journal of Medicine, which included 83% men, showed a positive screening rate of 0.9%. The preliminary results of the Cascade study are all the more alarming as the false positive rate is very low: 0.6%. The examination is in fact read four times, once by a generalist radiologist trained in this type of imaging, then by artificial intelligence software and finally by two experts.
These results corroborate the conclusions of KBP 2020, a epidemiological study, published on August 29, 2022 in The Lancet Regional Health, which makes it possible to draw up a precise inventory – every ten years since 2000 – of people with lung cancer. Of the 9,000 patients included from 82 pulmonology and pneumo-cancer departments in hospitals, the researchers observed a marked increase in women: in 2000, they represented 16% of new cases of primary bronchial cancer, twenty years later. , they are 34.6%. “This trend, confirmed and reinforced today, was revealed ten years ago during the second KBP study. Among the youngest patients, the proportion of women is particularly high: in 2020, out of 100 people under the age of 50 diagnosed with primary lung cancer, 41 were women”wrote the authors of the article.
Exponential increase
“In fifty years, we have gone from an archi-exceptional disease to a disease which tends to become, in France among women, the leading cause of death from cancer, ahead of breast cancer”, worries Marie-Pierre Revel. And this situation is all the more worrying since, according to the latest data from Public Health France, daily smoking among women is increasing. It fell from 20.7% to 23% between 2019 and 2021.
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