The “2022 International Symposium on Poisoning Prevention Research and Development” will be held in Beirong. (Provided by Beirong)
[Reporter Lin Huiqin/Taipei Report]Acetaminophen (APAP), an analgesic drug commonly used for antipyretics and analgesia, is used during the epidemic in response to symptoms caused by Wuhan pneumonia (new coronavirus disease, COVID-19) or vaccination. It has almost become a backup drug in every household, but at the “2022 International Symposium on Poisoning Prevention Research and Development” held today, experts reminded that overdose may lead to the risk of liver damage, and new domestic research progress has also shed light on the direction of detoxification.
APAP is a common cause of drug-induced acute liver failure worldwide. It is mainly due to the metabolism of the liver enzyme cytochrome P450 to produce highly active toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). The normal dose can usually be compared with glutathione (glutathione) ) combined to form non-toxic metabolites that are excreted by the kidneys, but if glutathione is exhausted at a toxic dose, it may cause liver cell necrosis.
Hu Youpu, a professor at the National Defense Medical College, pointed out that a new formula “SNP-810” developed in China has been found through animal experiments to eliminate liver damage and abnormal pathological results caused by high-dose APAP in rats and mice, even after taking the total dose. Up to 8000 mg/kg, which is equivalent to 70 kg of human beings, still survived after taking 90 grams.
Hu Youpu explained that further research has found that SNP-810 can reduce the formation of NAPQI, and is now developing safe drugs, hoping not only to eliminate toxic metabolites, but also to inhibit the formation of toxic metabolites.
Dr. Richard C. Dart, former president of the American Association of Poison Control Centers and director of the American Rocky Mountain Poison Drug Center, said that APAP also had a transient increase in alanine aminotransferase (ALT) at the recommended therapeutic dose. A study in Colorado showed that 204 subjects received 4 grams of APAP per day for at least 16 days. ALT was higher than 60 units/L at any monitoring time point, a total of 25, and a total of 179 were not increased. From Allantoate , Ornithine and other material differences, and further understand the relevant mechanisms.
In the seminar, Dr. Winai Wananukul, director of the Ramatibodi Poison Center in Thailand, shared that the explosive growth of e-commerce has made it easy for people who want to harm themselves to come into contact with toxic substances. Recently, young people have suffered sudden cardiovascular failure , a middle-aged man with hypotension and cardiac arrest, a young man with severe vomiting and abdominal pain after taking white powder, and finally determined that the exposed substances were potassium cyanide, sodium azide, and hen mother pearl powder, which were obtained by the patient through online shopping Substances, reminding that there should be countermeasures.
The Foundation for Poison Prevention and Development, Beirong Occupational Medicine and the Department of Clinical Toxicology held the “2022 International Symposium on Poison Prevention Research and Development-New Trends in Clinical Poisoning” for two consecutive days yesterday. In addition to the online participation of 2 British scholars, there were also Twelve experts from the United States, France, Norway, Japan, Thailand, Vietnam, the Philippines, Malaysia, Indonesia, India and other places arrived in Taiwan to discuss many important poisoning issues such as drug abuse, poisonous snake bites, and terrorist poisoning.
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