2023-10-23 04:01:53
Sneezing, runny nose, itchy eyes, tears, asthma, itching… While more than a million French people are allergic to cats, there is currently no vaccine to treat this allergy in humans, caused by “an extremely volatile protein (Fel D1) that the cat deposits on its fur when it licks itself” explains Loïc Faye, co-founder of Angany and technical director of Angany Innovation. So far, the only method to alleviate cat allergy is desensitization, which can take years. With this vaccine, it would be enough “probably d’one or two vaccinations per year so that people with allergies are completely protected and are gradually treated” projects Loïc Faye.
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Clinical trials on patients
Since the beginning of October, twenty people allergic to cats test the ANG-101 vaccine candidate at Imperial College London and “according to animal tests, we can anticipate that it is very effective” assures the scientist. For three months in the United Kingdom then, during the first half of 2024 in France on around fifty patients, the safety of the product will be tested, “before very quickly behind, a phase of efficiency” continues Véronique Gomord, co-founder and scientific director of Angany. In London, the sick “receive two injections in two different forms of the product and are followed for seven days afterwards to check that they have no reaction at all”.
This phase of clinical trials gave rise to many hopes among people allergic to cats: “The phase which began in October is going much faster than expected. We think it will be finished in early or mid-December and patients are coming forward in France or Canada to enter clinical trials.” reports Véronique Gomord.
How it works ?
This vaccine is “a particle which mimics a viral envelope and which carries the major cat allergen on its surface. When we inject this particle into the patient, the vaccine will deceive the immune system since it presents itself as a virus and we will trigger a very very strong protective reaction and produce antibodies to counteract and cure the disease. explains Véronique Gomord. However, the road is still long before this vaccine hits the market: “Six to seven years” believes Loïc Faye, after the safety and effectiveness phases and the marketing authorizations delivered by the FDA (Food and Drug Administration) for North America and the EMA (European Medicines Agency / Agence Européenne du Médicament). ) for the European Union.
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From the first quarter of 2024, Angany will test another vaccine on owned dogs intended to treat canine atopic dermatitis, the second reason for visiting veterinarians, after vaccines.
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