BEIJING, Jan. 26 (Xinhua) — A study published this week in the journal Cell Discovery revealed that a group of Chinese virologists has developed a technique to help preserve vaccines. Prevents novel coronavirus infection (COVID-19) type mRNA at normal temperature for more than half a year
Currently, most mRNA vaccines need to be stored at -20°C to -70°C due to their low stability which limits their availability.
The results showed that freeze-dried evaporated lipid nanoparticle (LNP) vaccines. prepared via freeze drying technique (lyophilization) with precise temperature control and lower residual water content It was able to maintain its physicochemical stability at 25 °C for more than 6 months, coupled with potent aqueous and cellular immunity activation in mice, rabbits or macaques.
Human trials have shown that vaccination against the virus mutant type Omicron species The new form is a stimulant dose. It also builds strong immunity. The titer or neutralizing antibodies against the virus Omicron species many subspecies at least a 253-fold increase after this booster dose following two doses of the commercially inactivated vaccine.
The researchers said the new technique overcomes the instability of mRNA vaccines. without affecting the bioactivity of the vaccine and significantly increase their reach. especially in remote regions
(Xinhua file photo: COVID-19 vaccine mRNA type at the 4th China International Import Expo in Shanghai, east China, Nov. 7, 2021).