Pediatrician Annie Andrews defeated GOP Senator Darline Graham in South Carolina’s Senate race, securing a historic upset that makes her the first woman to win a Senate election in the state and the first Democrat elected to the chamber there since 1998, according to NPR and the Associated Press.
Andrews Built Her Campaign Around Economic Accessibility
Andrews built the core of her campaign around economic accessibility, drawing directly from her clinical background treating pediatric patients with chronic conditions. “I would diagnose kids with common chronic diseases like asthma and diabetes, and I found that while I would explain my treatment plan to the parents so often, they would say, ‘Well, how much is that inhaler going to cost?’ Or ‘How much is that insulin going to cost?'” Andrews told NPR in an interview last month. “No parent in America should have to be thinking about their pocketbook when they’re hearing news that their child has a chronic illness.”
Financial Barriers Force Families to Weigh Household Budgets
- Economic Toxicity in Chronic Disease Management: Financial barriers directly impact treatment adherence for pediatric conditions like asthma and diabetes, forcing families to weigh household budgets against vital physiological interventions.
Associated Press Race Call Confirmed the Unexpected Victory
The Associated Press race call confirmed the unexpected victory in South Carolina, a state President Trump won by nearly 18 points in 2024. Graham had been appointed to the seat following the July death of her brother, longtime Republican Senator Lindsey Graham. During her brief tenure, Graham served as a reliable vote for Trump, supporting his administration on executive nominations, such as confirming Todd Blanche as Attorney General, and defending executive war powers against Democratic challenges.
Despite the state’s deep conservative lean, the incumbent faced significant headwinds as presidential approval ratings dropped before the midterms. Public opposition to the war in Iran, tariff policies, and high energy prices created a difficult electoral map for Republicans. Democrats needed a net gain of four seats to flip Senate control, driving a broader competitive strategy that reached deep into traditionally red states like South Carolina, Kansas, and Texas, alongside battleground wins such as former Democratic Governor Roy Cooper securing a Senate seat in North Carolina.

| Race / State | Winning Candidate | Prior Party Control / Context |
|---|---|---|
| South Carolina Senate | Annie Andrews (Democrat) | GOP-held seat; first Democratic win since 1998 |
| North Carolina Senate | Roy Cooper (Democrat) | Key battleground pickup |
References
- National Public Radio (npr.org) – Midterm Election Coverage and Candidate Interviews
- Associated Press – Senate Race Calls
More on Democrat Annie Andrews
BREAKING: Democrat Annie Andrews wins U. S. Senate race in South Carolina, NBC News projects. https://t.co/nBIBkG3e7E pic.twitter.com/qnWosIlniP