Quick screening is a microneedle patch to extract subcutaneous tissue fluid. (Provided by Tushan University)
[Reporter Fang Zhixian/Kaohsiung]The COVID-19 epidemic is raging, and many chronically ill patients are worried that they will not be able to go to the hospital for screening as scheduled, thus delaying their treatment. The team of Yang Hongwei, a professor at the Institute of Medical Science and Technology of Sun Yat-sen University, and the team of Tian Youlin, a pediatric nephrologist at Kaohsiung Chang Gung Hospital, have developed a bloodless and painless rapid screening reagent for chronic kidney disease with the support of an inter-institutional cooperation program. The results can be known within 20 minutes, which can not only avoid delays in the disease, but also avoid clusters and reduce the risk of infection.
The research and development team of Sun Yat-Sen University and Kaohsiung Chang Gung pointed out that human gut microbes will produce trimethylamine (TMA) from red meat and other foods we eat, which will be converted into trimethylamine oxide (TMAO) by the liver, increasing the risk of cardiovascular disease. risk. When diagnosing chronic kidney patients, TMAO is considered to be one of the urinary toxins involved in the production of hypertension.
Please read on…
In recent years, a large number of research literatures have pointed out that a faster and more sensitive detection method than Creatinine GFR is to detect Cystatin C (Cystatin C) in the body to detect early chronic kidney disease, without the interference of renal tubular reabsorption, and also. Does not vary by age, gender, body weight and muscle mass. Therefore, the detection and relative quantification of cystin C is of great significance for the diagnosis and treatment of chronic kidney disease and hypertension.
Yang Hongwei emphasized that this quick sieve uses a microneedle patch to extract subcutaneous tissue fluid, and combines with a lateral flow test piece (ie, a pregnancy test stick test piece) to perform a bloodless and painless quick sieve, “as long as the tissue fluid is drawn directly Press the microneedle on the test piece, and then drop the buffer solution. The relative concentration of cystin C in the subcutaneous tissue fluid can be read in about 15 to 20 minutes, and the patient can be warned as soon as possible.
“During the epidemic, if patients can self-monitor chronic kidney disease at home, it will be able to avoid delays and clustering, and greatly reduce the burden on hospitals.” Yang Hongwei said that this rapid screening technology has achieved good results in animal experiments. The results have been published in the top international journals Biosensors and Bioelectronics. Currently, the cross-school team is planning a human trial, which is expected to be applied to regular home monitoring of chronic kidney disease in the future.
The research team also includes Guo Shaowei (co-corresponding author), Distinguished Professor of the Department of Materials and Optoelectronics of Sun Yat-sen University, Chen Yijun, a master student of the Institute of Medical Science and Technology, Xu Yingpei, a doctoral candidate of the Department of Materials and Optoelectronics, Li Nanxi and Pang, postdoctoral fellows of the Institute of Medical Science and Technology. Haohan.
The team of Yang Hongwei, a professor at the Institute of Medical Science and Technology of Sun Yat-Sen University, has developed a rapid screening reagent for chronic kidney disease through cross-college cooperation. (Provided by Tushan University)
☆Do not miss health news, follow by likefan page。
☆For more important medical news, please go toFree Health Network。
No need to draw, no need to grab, now use the APP to watch the news to ensure that you will win the lottery every dayClick me to download APP
Follow me to see how the event works