2024-02-29 01:09:39
A related paper was published in the Journal of Diabetes Treatment, an SCI-level international academic journal.
Discovery of oral lactic acid bacteria Lactiplantibacillus plantarum DM083
Spurring research to prove the functionality of oral-derived beneficial bacteria
Apple Tree Medical Foundation and Dax Medioral Biome Co., Ltd. recently published a research paper in the Journal of Diabetes Treatment, an SCI-level international academic journal, stating that ‘oral-derived lactic acid bacteria can have a positive effect on lowering blood sugar levels.’ Photo = Apple Tree Medical Foundation
Research results have been published showing that oral lactic acid bacteria can have a positive effect on lowering blood sugar levels.
Apple Tree Medical Foundation (Chairman Kim Hye-seong) and Dax Medioral Biome Co., Ltd. (hereinafter referred to as Dax Medi), a company specializing in microbiome-based oral care, recently published this information in the Journal of Diabetes and Treatment, an SCI-level international academic journal. Dam announced that he had published a research paper.
In this study, researchers discovered the lactic acid bacterium Lactiplantibacillus Plantarum DM083, which has excellent efficacy in lowering blood sugar, from the oral cavity of Koreans. This is significant in that it suggests that specific lactic acid bacteria living in the oral cavity can regulate insulin and sugar metabolism, which are closely related to systemic health.
Officials from the Daxmedi Corporate Research Institute and the Apple Tree Medical Foundation Biomedical Research Institute said, “We introduced the Drosophila model in this research process and found Lactiplantibacillus Plantarum DM083, which has excellent blood sugar lowering efficacy among 168 different lactic acid bacteria strains.” He explained, “It was an opportunity to dramatically overcome the technical limitations faced by existing lactic acid bacteria research.”
According to officials, since lactic acid bacteria generally produce various acidic substances, it is impossible to test the efficacy of lactic acid bacteria in cell models that are vulnerable to acidic environments. In addition, although it is possible to test the efficacy of lactic acid bacteria in a mouse model, it is expensive and time-consuming to find a target strain with the desired efficacy among a large number of lactic acid bacteria strains.
Senior researcher Jeong-hoo Lee said, “Lactiplantibacillus plantarum DM083 can exert a blood sugar-lowering effect by promoting the secretion of specific intestinal hormones in the intestines of fruit flies and then moving to insulin-secreting cells and increasing insulin gene expression.” “Because the insulin and sugar metabolism processes of Lactiplantibacillus Plantarum DM083 are almost similar to those of mice, the blood sugar-lowering effect of Lactiplantibacillus Plantarum DM083 can be fully demonstrated in mice and humans,” he said.
Meanwhile, Dax Medi and Apple Tree Medical Foundation have begun animal testing and human application testing since the end of last year to find out the blood sugar-lowering efficacy of Lactiplantibacillus Plantarum DM083.
Chairman Kim Hye-seong (Apple Tree Medical Foundation), who participated in the research, said, “We expect that the products of these research efforts will bring about innovation in the medical field, including dentistry,” and added, “We will continue to accelerate research to prove the functionality of oral beneficial bacteria.” It was said.
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