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New study on statins: do not rejoice too quickly
A recent study has just demonstrated the superiority of the effects of a statins (to rosuvastatin) low-dose on blood lipids compared to six of the most commonly consumed dietary supplements in the United States. 190 adults, aged 40 to 75, all with no cardiovascular history, were divided into eight groups, which took either rosuvastatin 5 mg/d, or a placebo, or one of the six dietary supplements such as curcumin, fish oil, cinnamon, allicin. In addition, a lipid assessment was carried out at the beginning and at the end of this experiment, the main conclusions of which are as follows:
- the lower LDL-cholesterol (the “bad” cholesterol) was 37.9% when taking a statin, and equal to that observed with the placebo when taking one of the six dietary supplements;
- similar observations with total cholesterol and triglycerides ;
- even better: the intake of phytosterols has been associated with a drop in HDL-cholesterol (the “good”) and that of allicin (effective molecule of garlic) with an increase in LDL-cholesterol.
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There is no doubt that these results will be highly publicized. However, certain remarks must strongly temper this beautiful enthusiasm:
- the more a study covers a larger number of individuals, the more its results are statistically significant. Here, the population studied is not large enough for the published conclusions to have an indubitable reference value;
- the duration of the study is too short (two years) to judge the real effects of these various “treatments” in terms of cardiovascular prevention;
- no mention is made of the eating habits of the volunteers, whose prime importance we know;
- finally, most of the authors of the study admitted working for one or more pharmaceutical laboratories.
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The association cholesterol, cardiovascular risk and statins once again called into question
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