2023-05-22 04:05:12
A new study finds that parts of toxic gut bacteria can seep into the bloodstream and damage fat cells, leading to weight gain.Guardian“.
The researchers at Nottingham Trent University said their findings help shed light on how endotoxins may be driving obesity and related diseases such as type 2 diabetes.
In the study, recently published in the UK medical journal BMC, researchers evaluated 156 people, of whom 63 were classified as obese.
The researchers examined two types of fat cells: white fat cells, which store energy, and brown fat cells, which use energy and are linked to metabolic activity.
Their goal was to understand the role of endotoxins in increasing the risk of obesity and type 2 diabetes.
The researchers found that the white fat cells of obese people were less likely to turn into brown fat cells, compared to those of lean individuals.
The researchers said this was likely due to the higher levels of endotoxins found in the blood of obese participants.
Endotoxins are toxic substances that are found within the bacterial cell walls and are released when they rupture or disintegrate. In a healthy gut, endotoxins are part of the life cycle of microbes that play a major role in overall human health.
But in obese people, the gut barrier is more fragile, which allows endotoxins to enter the blood and thus other parts of the body.
“Gut microbiomes entering the bloodstream reduce normal fat cell function and metabolic activity, which exacerbates with weight gain, contributing to an increased risk of developing diabetes,” said lead study author Mark Christian.
“It appears that as weight increases, fat stores become less able to limit the damage that parts of the gut microbiome may cause to fat cells.”
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