Flu: Vaccines go well with rampant viruses

Flu

The influenza vaccines for the 2022/2023 season go well with the “flu” pathogens that are actually already rampant. This has been proven by US scientists in laboratory tests. This means that there is still a good chance of being vaccinated against influenza.

A corresponding lead time is required for the production of influenza vaccines. That is why the production is always dependent on the recommendations of the World Health Organization (WHO) for the use of the antigens of certain influenza A and influenza B antigens for the vaccines of the coming “flu” season.

Each of the mostly four antigen components in the vaccines (two for influenza A, two for influenza B viruses) does not always “fit” perfectly with the pathogens that are actually rampant. This leads to lower protection rates.

Derive high protective effect

For 2022/2023, all people who want to protect themselves against influenza can most likely rely on the vaccine. That goes from the Influenza Surveillance Report from the US Centers for Disease Control CDC on December 2nd. Experts from the US agency had immunized ferrets with the vaccines produced for this “flu” season (either based on hen’s eggs or produced in cell cultures, etc.). Then their blood sera were brought into contact with the currently rampant pathogens.

The main results, according to the German Pharmaceutical Newspaper: “According to the CDC report, 96 percent of the currently isolated influenza A H1N1 viruses (46 of 48) were detected by ferret antisera in the experiments. The animals had previously been vaccinated with either a current-season egg-based or cell-based influenza vaccine. With the current influenza A H3N2 viruses, the detection rate for the cell-based vaccines was even one hundred percent (60 out of 60) and for the chicken egg vaccines 97 percent (58 out of 60).”

In the case of the influenza B viruses – these strains usually lead to milder diseases than influenza A pathogens – only one B/Victoria strain isolated from one patient could be tested against ferret sera. This also resulted in a high detection rate. One of the reference pathogens used was B/Austria/1359417/2021, a cell culture virus originating from Austria.

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