Genomic Center worried about the ‘Omicron’ subspecies coming back violently vaccination extract The World Health Organization will keep an eye on the next 2-4 weeks.
on May 9 Medical Genome Center Faculty of Medicine Hospital (Hospital) Ramathibodi, Mahidol University latest facebook post Expressing concern about the Covid-19 Omicron or Ohmicron subspecies that are spreading abroad.
The message states that A mutation in the coronavirus 2019 genome at the spike gene at “452” may be a factor in “Omicron subspecies BA.4, BA.5, and BA.2.12.1” The watchdog has the ability to spread faster (high transmissibility) and may also have the ability to connect cell walls (lungs) from multiple cells into a single cell. The fusogenicity, or multinucleated syncytial pneumocytes, can cause inflammation of the lung tissue, as is the case with past outbreaks of “delta” strains.
From the 2019 coronavirus genome decoding, the entire genome showed changes in the thorn region at “452” from the amino acid “leucine (L)” to “arginine (R)” or “A. Lutamine (Q)” (Figure 1) gives the barbs the property that can connect neighboring cell walls. Cell fusion or syncytia formation allows the virus to rapidly spread cell-to-cell without leaving the cell at risk of being captured and destroyed by antibodies created in the host’s body. Natural and vaccinated The lung cells infected with the 2019 coronavirus fuse into a single cell (infected multinucleated syncytial pneumocytes) are large cells within a multinucleated cell. The DNA inside these cells is broken and broken. This causes the immune system of an infected person to view them as foreign and invade and destroy those multinucleated cells (syncytial pneumocytes), leading to further inflammation leading to pneumonia, which can cause severe illness.
The “delta” species has a thorn mutation as “R452”. (Pictures 1 and Fig. 2, red-framed) A high pathogenicity of infection is caused by syncytial pneumocytes.
In contrast to the original omicron strains (B.1.1529) such as BA.1, BA.1.1 and BA.2, there were no mutations in these regions. The amino acid remains “L452” (Fig. 1 and Fig. 2, green-framed), consistent with the mild clinical manifestations of the original Omicron strain. One reason may be that syncytial pneumocytes are not formed in the infected lung cells.
But the concern is the virus. “BA.4” and “BA.5” The WHO declared surveillance due to an outbreak in South Africa had a mutation of R452 (Fig. 1 and Figure 2), while the BA.2.12.1 virus that had spread in the United States had a mutation of “Q452”. (Fig. 1 and Fig. 2, yellow-framed) Back to “delta” strains (Fig. 1 and Fig. 2, red framed), possibly causing multiple infected cells to fuse into a single cell (syncytial pneumocytes).
Therefore, it is likely that omicron substituents BA.4, BA.5, BA.2.12.1 may be infected with more severe symptoms than the original omicron strain, which WHO and scientists around the world are monitoring for clinical symptoms. Clinics closely infected with BA.4, BA.5 and BA.2.12.1 from South Africa and the United States. Expect results in 2-4 weeks from now. The latest update shows that the number of patients requiring hospitalization in the two countries has begun to increase. But the death rate remains the same.
Therefore, the vaccine should be vaccinated if it has not been vaccinated and the booster needle will be administered when it is due to prevent re-infection if an outbreak of omicron subspecies BA.4, BA.5 and BA.2.12.1 enters Thailand. Because natural immunity from the original omicron strain or from the last dose of vaccine administered more than four months may not protect us much from the emerging subspecies of omicron.
Professor Alex Sigal Virologist at the African Institute of Health Research in South Africa. Beta coronavirus founder and omicron substituents BA.4 and BA.5 indicate that from laboratory tests it was found that vaccination and needle-infected boosters would significantly reduce morbidity and mortality. statistics It also produces hybrid immunity, which has broader immunity to combat newly emerged omicrons.
reference
– https://www.nature.com/articles/s41392-022-00941-z
– https://edition.cnn.com/2022/05/03/health/fitter-omicron-descendants-covid-variants/index.html
– https://www.nbcnews.com/health/health-news/omicron-subvariants-mean-reinfection-risk-rcna26973
– Omicron sub-lineages BA.4/BA.5 escape BA.1 infection elicited neutralizing immunity
– https://www.medrxiv.org/content/10.1101/2022.04.29.22274477v1
– https://www.forbes.com/sites/williamhaseltine/2022/01/26/birth-of-the-omicron-family-ba1-ba2-ba3-each-a