Blood poisoning not primarily the result of an overly strong immune reaction?
Die blood poisoning (medical term: sepsis) is one of the most common causes of death worldwide. It was previously assumed that this life-threatening complication in a wide variety of infectious diseases was mainly the result of excessive Immune reaction is. But researchers are now reporting that the immune response is already significantly reduced after a short time.
Experts have so far assumed that sepsis and multi-organ failure are primarily the result of an excessive immune response. But even on the first day of blood poisoning, an immune response that is rather weak is visible. This has been determined by researchers who recently published their results in the journal “PLOS One“ have published.
Immune response rapidly decreased
A current one Message According to an interdisciplinary team from the Clinic for Anaesthesiology and Intensive Care Medicine (Prof. Dr. J. Peters) and the Institute for Medical Microbiology (Prof. Dr. C. Kirschning) of the Medical Faculty of the University of Duisburg-Essen, blood samples from intensive care patients patients found that the immune response is already significantly reduced on the first day of sepsis.
“The blood showed though high inflammatory valuesbut reacted to toll-like receptor ligands, bacteria and bacterial lipopolysaccharide in the test tube only to a lesser extent than in whole blood from healthy people, all of which are factors that otherwise actually cause a strong immune reaction.”explains Willem Buys, doctoral student at Essen University Hospital and co-first author.
“In addition, there was no reaction ex vivo to so-called Immune Checkpoint Inhibitorsa group of drugs already used in cancer therapy and currently being considered as a possible therapy for sepsis to boost the immune response”, says first author Dr. medical Alexandra Bick from the Clinic for Anesthesiology and Intensive Care Medicine.
The question of whether activation of the immune response is still possible Sepsistherapie could be suitable, the scientists would like to investigate in follow-up studies. (ad)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- University of Duisburg-Essen: Immune reaction in sepsis: too strong, too weak or both?, (accessed: September 24th, 2022), university Duisburg-Essen
- Alexandra Bick, Willem Buys, Andrea Engler, Rabea Madel, Mazen Atia, Francesca Faro, Astrid M. Westendorf, Andreas Limmer, Jan Buer, Frank Herbstreit, Carsten J. Kirschning, Jürgen Peters: Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria; in: PLOS One, (veröffentlicht: 18.08.2022), PLOS One
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.